RegulonDB RegulonDB 11.1: Gene Form
   

setA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

setA leuD sgrS sgrT terminator anti-terminator anti-anti-terminator TSS_123 TSS_123 TSS_122 TSS_122

Gene      
Name: setA    Texpresso search in the literature
Synonym(s): ECK0072, EG11754, b0070, yabM
Genome position(nucleotides): 77621 --> 78799
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 48.52
External database links:  
ASAP:
 ABE-0000257
ECHOBASE:
 EB1704
ECOLIHUB:
 setA
OU-MICROARRAY:
 b0070
STRING:
 511145.b0070
COLOMBOS: setA


Product      
Name: sugar exporter SetA
Synonym(s): SetA, YabM
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 42.713
Isoelectric point: 9.794
Motif(s):
 
Type Positions Sequence Comment
11 -> 31 MNGVYAAFMLVAFMMGVAGAL UniProt: Helical.
19 -> 345 MLVAFMMGVAGALQAPTLSLFLSREVGAQPFWIGLFYTVNAIAGIGVSLWLAKRSDSQGDRRKLIIFCCLMAIGNALLFAFNRHYLTLITCGVLLASLANTAMPQLFALAREYADNSAREVVMFSSVMRAQLSLAWVIGPPLAFMLALNYGFTVMFSIAAGIFTLSLVLIAFMLPSVARVELPSENALSMQGGWQDSNVRMLFVASTLMWTCNTMYIIDMPLWISSELGLPDKLAGFLMGTAAGLEIPAMILAGYYVKRYGKRRMMVIAVAAGVLFYTGLIFFNSRMALMTLQLFNAVFIGIVAGIGMLWFQDLMPGRAGAATTLFT
49 -> 69 FWIGLFYTVNAIAGIGVSLWL UniProt: Helical.
82 -> 102 LIIFCCLMAIGNALLFAFNRH UniProt: Helical.
107 -> 127 ITCGVLLASLANTAMPQLFAL UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters
  5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005351 - carbohydrate:proton symporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0055085 - transmembrane transport
GO:0015767 - lactose transport
GO:0034219 - carbohydrate transmembrane transport
GO:1902600 - proton transmembrane transport
GO:0036448 - cellular response to glucose-phosphate stress
GO:1904659 - glucose transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P31675
ECOCYC:
 B0070-MONOMER
ECOLIWIKI:
 b0070
INTERPRO:
 IPR036259
INTERPRO:
 IPR020846
INTERPRO:
 IPR011701
INTERPRO:
 IPR004750
MODBASE:
 P31675
PANTHER:
 PTHR23535:SF2
PFAM:
 PF07690
PRIDE:
 P31675
PRODB:
 PRO_000023936
PROSITE:
 PS50850
REFSEQ:
 YP_025293
UNIPROT:
 P31675


Operon      
Name: sgrST-setA         
Operon arrangement:
Transcription unit        Promoter
sgrST-setA
sgrST-setA


Transcriptional Regulation      
Display Regulation             
Activated by: SgrR
Repressed by: Cra


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_122 79281 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_123 79386 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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