RegulonDB RegulonDB 11.1: Gene Form
   

gmm gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cpsB wcaI fcl gmm

Gene      
Name: gmm    Texpresso search in the literature
Synonym(s): ECK2045, EG11789, b2051, nudD, wcaH, yefC
Genome position(nucleotides): 2125743 <-- 2126222
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.58
External database links:  
ASAP:
 ABE-0006796
ECHOBASE:
 EB1737
ECOLIHUB:
 gmm
OU-MICROARRAY:
 b2051
STRING:
 511145.b2051
COLOMBOS: gmm


Product      
Name: GDP-mannose mannosyl hydrolase
Synonym(s): Gmm, NudD, WcaH, YefC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 18.273
Isoelectric point: 4.838
Motif(s):
 
Type Positions Sequence Comment
2 -> 3 FL UniProt: Substrate binding; Sequence Annotation Type: region of interest.
13 -> 153 RSTPLVSLDFIVENSRGEFLLGKRTNRPAQGYWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTHYVVLGFRFRVSEEELLLPDEQHDDYRWLTSDALLASDNVHANSRAYFLAEKR UniProt: Nudix hydrolase.
21 -> 21 D UniProt: Increases Km for GDP-mannose 9-fold. Reduces activity 400-fold..
22 -> 142 FIVENSRGEFLLGKRTNRPAQGYWFVPGGRVQKDETLEAAFERLTMAELGLRLPITAGQFYGVWQHFYDDNFSGTDFTTHYVVLGFRFRVSEEELLLPDEQHDDYRWLTSDALLASDNVHA
36 -> 36 R UniProt: Increases Km for GDP-mannose 9-fold. Reduces activity 24-fold..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.2 - colanic acid (M antigen)
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.10 - sugar nucleotide biosynthesis, conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0047917 - GDP-glucosidase activity
GO:0000287 - magnesium ion binding
GO:0030145 - manganese ion binding
GO:0008727 - GDP-mannose mannosyl hydrolase activity
biological_process GO:0009103 - lipopolysaccharide biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P32056
ECOCYC:
 GDPMANMANHYDRO-MONOMER
ECOLIWIKI:
 b2051
INTERPRO:
 IPR028613
INTERPRO:
 IPR033715
INTERPRO:
 IPR020084
INTERPRO:
 IPR015797
INTERPRO:
 IPR000086
MODBASE:
 P32056
PDB:
 1RYA
PDB:
 2GT2
PDB:
 2GT4
PFAM:
 PF00293
PRIDE:
 P32056
PRODB:
 PRO_000023422
PROSITE:
 PS51462
PROSITE:
 PS00893
REFSEQ:
 NP_416555
SMR:
 P32056
UNIPROT:
 P32056


Operon      
Name: wcaCDEF-gmd-fcl-gmm-wcaI-cpsBG-wcaJ-wzxC         
Operon arrangement:
Transcription unit        Promoter
wcaCDEF-gmd-fcl-gmm-wcaI-cpsBG-wcaJ-wzxC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB