RegulonDB RegulonDB 10.10: Gene Form
   

pepE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yjbB rluF pepE lysC5\' rluFp1 rluFp1 TSS_4846 TSS_4846 rluFp6 rluFp6 TSS_4845 TSS_4845 TSS_4844 TSS_4844

Gene      
Name: pepE    Texpresso search in the literature
Synonym(s): ECK4013, EG11920, b4021
Genome position(nucleotides): 4229453 <-- 4230142 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
54.35
External database links:  
ASAP:
ABE-0013146
CGSC:
34261
ECHOBASE:
EB1864
ECOLIHUB:
pepE
OU-MICROARRAY:
b4021
STRING:
511145.b4021
COLOMBOS: pepE


Product      
Name: peptidase E
Synonym(s): PepE, peptidase E, a dipeptidase where amino-terminal residue is aspartate
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 24.57
Isoelectric point: 5.931
Motif(s):
 
Type Positions Sequence
3 -> 205 LLLLSNSTLPGKAWLEHALPLIAEQLQGRRSAVFIPFAGVTQTWDDYTAKTAAVLAPLGVSVTGIHSVVDPVAAIENAEIVIVGGGNTFQLLKQCRERGLLAPITDVVKRGALYIGWSAGANLACPTIRTTNDMPIVDPQGFDALNLFPLQINPHFTNALPEGHKGETREQRIRELLVVAPELTIIGLPEGNWITVSKGHATL

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0008236 - serine-type peptidase activity
GO:0016805 - dipeptidase activity
biological_process GO:0006508 - proteolysis
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-48072N
ECOCYC:
EG11920-MONOMER
ECOLIWIKI:
b4021
INTERPRO:
IPR023172
INTERPRO:
IPR029062
INTERPRO:
IPR005320
MODBASE:
P0A7C6
PFAM:
PF03575
PRIDE:
P0A7C6
PRODB:
PRO_000023510
REFSEQ:
NP_418445
SMR:
P0A7C6
SWISSMODEL:
P0A7C6
UNIPROT:
P0A7C6


Operon      
Name: pepE         
Operon arrangement:
Transcription unit        Promoter
pepE


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4844 4229853 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4845 4229873 reverse nd [RS-EPT-CBR] [1]
  promoter rluFp6 4230162 forward nd [ICWHO] [2]
  promoter TSS_4846 4230168 reverse nd [RS-EPT-CBR] [1]
  promoter rluFp1 4230309 forward nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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