RegulonDB

Gene
Name:	yadV
Synonym(s):	ECK0139, EG11973, b0140, ecpD
Genome position(nucleotides):	155461 <-- 156201
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	44.4
External database links:

ASAP:	ABE-0000482
CGSC:	30513
ECHOBASE:	EB1916
ECOLIHUB:	ecpD
OU-MICROARRAY:	b0140
STRING:	511145.b0140
COLOMBOS:	yadV

Gene

Name:

yadV

Synonym(s):

ECK0139, EG11973, b0140, ecpD

Genome position(nucleotides):

155461 <-- 156201

Strand:

reverse

Sequence:

Get nucleotide sequence FastaFormat

GC content %:

44.4

External database links:

ASAP:

CGSC:

ECHOBASE:

ECOLIHUB:

OU-MICROARRAY:

STRING:

COLOMBOS:

Product

Name:

putative fimbrial chaperone YadV

Synonym(s):

EcpD, YadV

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

periplasmic space

Molecular weight:

27.054

Isoelectric point:

9.677

Motif(s):

Type	Positions	Sequence	Comment
	1 -> 25	MFFNTKHTTALCFVTCMAFSSSSIA
	26 -> 246	DIVISGTRVIYKSDQKSVNVRLENKGNNPLLVQSWLDTGDDNAEPGSITVPFTATPPVSRIDAKRGQTIKLMYTASTSLPKDRESVFWFNVLEVPPKPDAEKVANQSLLQLAFRTRIKLFYRPDGLKGNPSEAPLALKWFWSGSEGKASLRVTNPTPYYVSFSSGDLEASGKRYPIDVKMIAPFSDEVMKVNGLNGKANSAKVHFYAINDFGGAIEGNARL	UniProt: Probable fimbrial chaperone YadV.
	27 -> 152	IVISGTRVIYKSDQKSVNVRLENKGNNPLLVQSWLDTGDDNAEPGSITVPFTATPPVSRIDAKRGQTIKLMYTASTSLPKDRESVFWFNVLEVPPKPDAEKVANQSLLQLAFRTRIKLFYRPDGLK
	79 -> 79	A	UniProt: In Ref. 1; AAA23720..
	110 -> 111	SV	UniProt: In Ref. 1; AAA23720..

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
Gene Ontology Terms (GO)
	cellular_component	GO:0030288 - outer membrane-bounded periplasmic space GO:0042597 - periplasmic space
	biological_process	GO:0007155 - cell adhesion GO:0043711 - pilus organization GO:0071555 - cell wall organization GO:0061077 - chaperone-mediated protein folding

Note(s):

Note(s): ...[more].

Evidence:

[COMP-HINF-FN-FROM-SEQ] Human inference of function from sequence
[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Korea CG., et al., 2011
[2] Larsonneur F., et al., 2016
[3] Raina S., et al., 1993
[4] Wurpel DJ., et al., 2013

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PFAM:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	IHF

Transcriptional Regulation

Display Regulation

Activated by:

IHF

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	htrEp5	155438		reverse	nd	[COMP-AINF]	[5]
	promoter	htrEp1	155518		reverse	nd	[COMP-AINF]	[5]

Type

Name

Post Left

Post Right

Strand

Notes

Evidence (Confirmed, Strong, Weak)

References

promoter

htrEp5

155438

reverse

[COMP-AINF]

[5]

promoter

htrEp1

155518

reverse

[COMP-AINF]

[5]

Evidence
[COMP-AINF] Inferred computationally without human oversight

Evidence

[COMP-AINF] Inferred computationally without human oversight

Reference(s)
[1] Korea CG., Ghigo JM., Beloin C., 2011, The sweet connection: Solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli: Multiple E. coli fimbriae form a versatile arsenal of sugar-binding lectins potentially involved in surface-colonisation and tissue tropism., Bioessays 33(4):300-11
[2] Larsonneur F., Martin FA., Mallet A., Martinez-Gil M., Semetey V., Ghigo JM., Beloin C., 2016, Functional analysis of Escherichia coli Yad fimbriae reveals their potential role in environmental persistence., Environ Microbiol 18(12):5228-5248
[3] Raina S., Missiakas D., Baird L., Kumar S., Georgopoulos C., 1993, Identification and transcriptional analysis of the Escherichia coli htrE operon which is homologous to pap and related pilin operons., J Bacteriol 175(16):5009-21
[4] Wurpel DJ., Beatson SA., Totsika M., Petty NK., Schembri MA., 2013, Chaperone-usher fimbriae of Escherichia coli., PLoS One 8(1):e52835
[5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Reference(s)

[1] Korea CG., Ghigo JM., Beloin C., 2011, The sweet connection: Solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli: Multiple E. coli fimbriae form a versatile arsenal of sugar-binding lectins potentially involved in surface-colonisation and tissue tropism., Bioessays 33(4):300-11

[2] Larsonneur F., Martin FA., Mallet A., Martinez-Gil M., Semetey V., Ghigo JM., Beloin C., 2016, Functional analysis of Escherichia coli Yad fimbriae reveals their potential role in environmental persistence., Environ Microbiol 18(12):5228-5248

[3] Raina S., Missiakas D., Baird L., Kumar S., Georgopoulos C., 1993, Identification and transcriptional analysis of the Escherichia coli htrE operon which is homologous to pap and related pilin operons., J Bacteriol 175(16):5009-21

[4] Wurpel DJ., Beatson SA., Totsika M., Petty NK., Schembri MA., 2013, Chaperone-usher fimbriae of Escherichia coli., PLoS One 8(1):e52835

[5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78