RegulonDB RegulonDB 11.1: Gene Form
   

btsS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

btsS mlrA btsR yehS FliZ yohOp6 yohOp6 mlrAp2 mlrAp2 mlrAp mlrAp mlrAp9 mlrAp9 mlrAp6 mlrAp6 TSS_2443 TSS_2443 TSS_2442 TSS_2442

Gene      
Name: btsS    Texpresso search in the literature
Synonym(s): ECK2118, EG12007, b2126, yehU
Genome position(nucleotides): 2212959 <-- 2214644
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.59
External database links:  
ASAP:
 ABE-0007027
ECHOBASE:
 EB1945
ECOLIHUB:
 yehU
OU-MICROARRAY:
 b2126
STRING:
 511145.b2126
COLOMBOS: btsS


Product      
Name: high-affinity pyruvate receptor
Synonym(s): BtsS, YehU
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 62.092
Isoelectric point: 8.609
Motif(s):
 
Type Positions Sequence Comment
4 -> 24 FNLVLLLLQQMCVFLVIAWLM UniProt: Helical.
27 -> 195 TPLFIPLMQVTVRLPHKFLCYIVFSIFCIMGTWFGLHIDDSIANTRAIGAVMGGLLGGPVVGGLVGLTGGLHRYSMGGMTALSCMISTIVEGLLGGLVHSILIRRGRTDKVFNPITAGAVTFVAEMVQMLIILAIARPYEDAVRLVSNIAAPMMVTNTVGAALFMRILL
44 -> 64 FLCYIVFSIFCIMGTWFGLHI UniProt: Helical.
73 -> 93 AIGAVMGGLLGGPVVGGLVGL UniProt: Helical.
109 -> 129 SCMISTIVEGLLGGLVHSILI UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0016301 - kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0000155 - phosphorelay sensor kinase activity
GO:0004673 - protein histidine kinase activity
GO:0033293 - monocarboxylic acid binding
biological_process GO:0016310 - phosphorylation
GO:0000160 - phosphorelay signal transduction system
GO:0007165 - signal transduction
GO:0031667 - response to nutrient levels
GO:0018106 - peptidyl-histidine phosphorylation
GO:0071555 - cell wall organization
Note(s): Note(s): ...[more].
Reference(s): [1] Zhao T., et al., 2021
External database links:  
ALPHAFOLD:
 P0AD14
DIP:
 DIP-11909N
ECOCYC:
 EG12007-MONOMER
ECOLIWIKI:
 b2126
INTERPRO:
 IPR003018
INTERPRO:
 IPR036890
INTERPRO:
 IPR011620
INTERPRO:
 IPR010559
MODBASE:
 P0AD14
PFAM:
 PF06580
PFAM:
 PF07694
PRIDE:
 P0AD14
REFSEQ:
 NP_416630
SMART:
 SM00065
SMR:
 P0AD14
UNIPROT:
 P0AD14


Operon      
Name: btsSR         
Operon arrangement:
Transcription unit        Promoter
btsSR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2442 2212969 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2443 2214673 reverse nd [RS-EPT-CBR] [2]
  promoter mlrAp6 2214749 forward nd [COMP-AINF] [3]
  promoter mlrAp9 2214785 forward nd [COMP-AINF] [3]
  promoter yohOp6 2215586 forward nd [COMP-AINF] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Zhao T., Xu L., Zhao L., Zhang H., Li Y., Zhang Y., 2021, BtsT/ BtsS is involved in glyoxylate transport in E. coli and its mutations facilitated glyoxylate utilization., Biochem Biophys Res Commun 551:71-77

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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