RegulonDB RegulonDB 11.1: Gene Form
   

cmoM gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mukF cmoM elyC mukE ycbJ TSS_1194 TSS_1194 cmoMp cmoMp

Gene      
Name: cmoM    Texpresso search in the literature
Synonym(s): ECK0912, EG12167, b0921, smtA, ycbD
Genome position(nucleotides): 973537 --> 974322
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.53
External database links:  
ASAP:
 ABE-0003131
ECHOBASE:
 EB2086
ECOLIHUB:
 smtA
OU-MICROARRAY:
 b0921
STRING:
 511145.b0921
COLOMBOS: cmoM


Product      
Name: tRNA cmo5U34 methyltransferase
Synonym(s): CmoM, SmtA, YcbD
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 29.814
Isoelectric point: 8.009
Motif(s):
 
Type Positions Sequence Comment
26 -> 26 R UniProt: Lack of activity..
33 -> 170 DLDRVLAEMGPQKLRVLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVASHLETPVDLILFHAVLEWVADPRSVLQTLWSVLRPGGVLSLMFYNAHGLLMHNMVAGNFDYVQA
52 -> 53 GG UniProt: S-adenosyl-L-methionine binding; Sequence Annotation Type: region of interest.
73 -> 73 D UniProt: Lack of activity..
102 -> 103 AQ UniProt: S-adenosyl-L-methionine binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.2 - RNA related --> 2.2.3 - RNA modification
  2 - information transfer --> 2.2 - RNA related --> 2.2.5 - tRNA
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0008168 - methyltransferase activity
GO:0016740 - transferase activity
GO:0097697 - tRNA 5-carboxymethoxyuridine methyltransferase activity
biological_process GO:0006400 - tRNA modification
GO:0030488 - tRNA methylation
GO:0008033 - tRNA processing
GO:0032259 - methylation
GO:0002098 - tRNA wobble uridine modification
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P36566
ECOCYC:
 EG12167-MONOMER
ECOLIWIKI:
 b0921
INTERPRO:
 IPR029063
INTERPRO:
 IPR025714
INTERPRO:
 IPR033664
MODBASE:
 P36566
PFAM:
 PF13489
PRIDE:
 P36566
PRODB:
 PRO_000023963
REFSEQ:
 NP_415441
SMR:
 P36566
UNIPROT:
 P36566


Operon      
Name: cmoM-mukFEB         
Operon arrangement:
Transcription unit        Promoter
smtA-mukFEB


Transcriptional Regulation      
Display Regulation             
Activated by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1194 975868 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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