RegulonDB RegulonDB 11.1: Gene Form
   

hemF gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

eutR hemF amiA IHF hemFp1 hemFp1 hemFp2 hemFp2 hemFp3 hemFp3

Gene      
Name: hemF    Texpresso search in the literature
Synonym(s): ECK2431, EG12189, b2436, popB, sec
Genome position(nucleotides): 2553225 --> 2554124
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.67
External database links:  
ASAP:
 ABE-0008034
CGSC:
 643
ECHOBASE:
 EB2106
ECOLIHUB:
 hemF
MIM:
 121300
OU-MICROARRAY:
 b2436
STRING:
 511145.b2436
COLOMBOS: hemF


Product      
Name: coproporphyrinogen III oxidase
Synonym(s): HemF, PopB, Sec
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 34.323
Isoelectric point: 6.351
Motif(s):
 
Type Positions Sequence Comment
7 -> 298 QVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREAGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGADPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGEDVYPRYKKWCDEYFYLKHRNEQRGIGGLFFDDLNTPDFDRCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDW
96 -> 96 H UniProt: Complete loss of oxidase activity and absence of manganese ions..
106 -> 106 H UniProt: Complete loss of oxidase activity and absence of manganese ions..
108 -> 110 NVR UniProt: Substrate binding; Sequence Annotation Type: region of interest.
145 -> 145 H UniProt: Complete loss of oxidase activity and absence of manganese ions..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.12 - heme, porphyrine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0004109 - coproporphyrinogen oxidase activity
GO:0046906 - tetrapyrrole binding
GO:0030145 - manganese ion binding
GO:0042803 - protein homodimerization activity
biological_process GO:0006779 - porphyrin-containing compound biosynthetic process
GO:0006783 - heme biosynthetic process
GO:0019353 - protoporphyrinogen IX biosynthetic process from glutamate
GO:0006782 - protoporphyrinogen IX biosynthetic process
GO:0033194 - response to hydroperoxide
External database links:  
ALPHAFOLD:
 P36553
ECOCYC:
 COPROGENOXI-MONOMER
ECOLIWIKI:
 b2436
INTERPRO:
 IPR018375
INTERPRO:
 IPR036406
INTERPRO:
 IPR001260
MODBASE:
 P36553
PANTHER:
 PTHR10755
PFAM:
 PF01218
PRIDE:
 P36553
PRINTS:
 PR00073
PRODB:
 PRO_000022875
PROSITE:
 PS01021
REFSEQ:
 NP_416931
SMR:
 P36553
SWISSMODEL:
 P36553
UNIPROT:
 P36553


Operon      
Name: amiA-hemF         
Operon arrangement:
Transcription unit        Promoter
amiA-hemF
hemF
hemF
hemF


Transcriptional Regulation      
Display Regulation             
Activated by: OxyR
Repressed by: IHF


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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