RegulonDB

RegulonDB RegulonDB 10.9: Gene Form

crcB gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	crcB
Synonym(s):	ECK0617, EG12209, b0624, ybeI
Genome position(nucleotides):	657555 <-- 657938 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	48.44
External database links:

ASAP:	ABE-0002144
ECHOBASE:	EB2123
ECOLIHUB:	crcB
OU-MICROARRAY:	b0624
STRING:	511145.b0624
COLOMBOS:	crcB

Product

Name:

F^- channel

Synonym(s):

CrcB, Fluc-Ec2, YbeI

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

13.777

Isoelectric point:

9.823

Motif(s):

Type	Positions	Sequence
	71 -> 91	TGFCGGLTTFSTFSAEVVFLL
	35 -> 55	LGTLTANLIGAFIIGIGFAWF
	4 -> 24	LLLAVFIGGGTGSVARWLLSM
	6 -> 116	LAVFIGGGTGSVARWLLSMRFNPLHQAIPLGTLTANLIGAFIIGIGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWALLNVFVNLLGSFAMTAL
	103 -> 123	VFVNLLGSFAMTALAFWLFSA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.6 - protection
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0015103 - inorganic anion transmembrane transporter activity GO:0005253 - anion channel activity GO:0042803 - protein homodimerization activity GO:1903425 - fluoride transmembrane transporter activity
	biological_process	GO:0140114 - cellular detoxification of fluoride GO:0034220 - ion transmembrane transport GO:1903424 - fluoride transmembrane transport

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PANTHER:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

crcB

Operon arrangement:

Transcription unit	Promoter
crcB

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_750	657301	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_751	657375	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_752	657964	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_753	657966	forward	nd	[RS-EPT-CBR]	[1]
promoter	crcBp3	657998	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.653. P-value: 2.473e-6 Read more >	[ICWHO]	[2]
promoter	crcBp4	658008	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 7.085. P-value: 7.505e-6 Read more >	[ICWHO]	[2]
promoter	tatEp3	658871	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.098. P-value: 1.827e-5 Read more >	[ICWHO]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

RegulonDB