RegulonDB RegulonDB 10.8: Gene Form
   

yiaY gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

selB aldB yiaY selA Fis Fis Fis CRP Fis Fis anti-anti-terminator anti-terminator terminator yiaYp6 yiaYp6 yiaYp4 yiaYp4 yiaYp7 yiaYp7 aldBp aldBp

Gene      
Name: yiaY    Texpresso search in the literature
Synonym(s): ECK3578, EG12293, b3589
Genome position(nucleotides): 3756676 <-- 3757827 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.52
External database links:  
ASAP:
ABE-0011725
ECHOBASE:
EB2201
OU-MICROARRAY:
b3589
PortEco:
yiaY
STRING:
511145.b3589
COLOMBOS: yiaY


Product      
Name: L-threonine dehydrogenase
Synonym(s): YiaY
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 40.351
Isoelectric point: 5.054
Motif(s):
 
Type Positions Sequence
10 -> 375 SVNVIGADSLTDAMNMMADYGFTRTLIVTDNMLTKLGMAGDVQKALEERNIFSVIYDGTQPNPTTENVAAGLKLLKENNCDSVISLGGGSPHDCAKGIALVAANGGDIRDYEGVDRSAKPQLPMIAINTTAGTASEMTRFCIITDEARHIKMAIVDKHVTPLLSVNDSSLMIGMPKSLTAATGMDALTHAIEAYVSIAATPITDACALKAVTMIAENLPLAVEDGSNAKAREAMAYAQFLAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVQVFNSKVAAARLRDCAAAMGVNVTGKNDAEGAEACINAIRELAKKVDIPAGLRDLNVKEEDFAVLATNALKDACGFTNPIQATHEEI
380 -> 383 RAAM

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0004022 - alcohol dehydrogenase (NAD+) activity
GO:0008743 - L-threonine 3-dehydrogenase activity
biological_process GO:0055114 - oxidation-reduction process
Note(s): Note(s): ...[more].
Reference(s): [1] Newman EB., et al., 1976
[2] Paradis-Bleau C., et al., 2014
[3] Rodriguez GM., et al., 2012
External database links:  
DIP:
DIP-12414N
ECOCYC:
EG12293-MONOMER
ECOLIWIKI:
b3589
INTERPRO:
IPR001670
INTERPRO:
IPR018211
INTERPRO:
IPR039697
MODBASE:
P37686
PANTHER:
PTHR11496
PFAM:
PF00465
PRIDE:
P37686
PROSITE:
PS00060
PROSITE:
PS00913
REFSEQ:
YP_026233
SMR:
P37686
SWISSMODEL:
P37686
UNIPROT:
P37686


Operon      
Name: yiaY         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yiaYp7 3757878 reverse Similarity to the consensus
Read more >
[ICWHO] [4]
  promoter yiaYp4 3757880 reverse Similarity to the consensus
Read more >
[ICWHO] [4]
  promoter yiaYp6 3757928 reverse Similarity to the consensus
Read more >
[ICWHO] [4]


Evidence    

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Newman EB., Kapoor V., Potter R., 1976, Role of L-threonine dehydrogenase in the catabolism of threonine and synthesis of glycine by Escherichia coli., J Bacteriol 126(3):1245-9

 [2] Paradis-Bleau C., Kritikos G., Orlova K., Typas A., Bernhardt TG., 2014, A genome-wide screen for bacterial envelope biogenesis mutants identifies a novel factor involved in cell wall precursor metabolism., PLoS Genet 10(1):e1004056

 [3] Rodriguez GM., Atsumi S., 2012, Isobutyraldehyde production from Escherichia coli by removing aldehyde reductase activity., Microb Cell Fact 11(1):90

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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