RegulonDB RegulonDB 11.1: Gene Form
   

ssuB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pepN ssuD ssuC ssuB ssuA CRP ssuBp3 ssuBp3 TSS_1246 TSS_1246 TSS_1245 (cluster) TSS_1245 (cluster)

Gene      
Name: ssuB    Texpresso search in the literature
Synonym(s): ECK0924, EG12358, b0933, ycbE
Genome position(nucleotides): 993277 <-- 994044
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.6
External database links:  
ASAP:
 ABE-0003173
ECHOBASE:
 EB2261
ECOLIHUB:
 ssuB
OU-MICROARRAY:
 b0933
STRING:
 511145.b0933
COLOMBOS: ssuB


Product      
Name: aliphatic sulfonate ABC transporter ATP binding subunit
Synonym(s): SsuB, YcbE
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,cytosol
Molecular weight: 27.738
Isoelectric point: 7.102
Motif(s):
 
Type Positions Sequence Comment
12 -> 233 LLLNAVSKHYAENIVLNQLDLHIPAGQFVAVVGRSGGGKSTLLRLLAGLETPTAGDVLAGTTPLAEIQEDTRMMFQDARLLPWKSVIDNVGLGLKGQWRDAARRALAAVGLENRAGEWPAALSGGQKQRVALARALIHRPGLLLLDEPLGALDALTRLEMQDLIVSLWQEHGFTVLLVTHDVSEAVAMADRVLLIEEGKIGLDLTVDIPRPRRLGSVRLAEL UniProt: ABC transporter.
27 -> 160 LNQLDLHIPAGQFVAVVGRSGGGKSTLLRLLAGLETPTAGDVLAGTTPLAEIQEDTRMMFQDARLLPWKSVIDNVGLGLKGQWRDAARRALAAVGLENRAGEWPAALSGGQKQRVALARALIHRPGLLLLDEPL
44 -> 51 GRSGGGKS UniProt: ATP.
133 -> 136 LSGG
153 -> 160 LLLLDEPL

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.2 - sulfur metabolism
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0042959 - alkanesulfonate transmembrane transporter activity
biological_process GO:0006790 - sulfur compound metabolic process
GO:0042918 - alkanesulfonate transport
GO:0010438 - cellular response to sulfur starvation
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0AAI1
ECOCYC:
 YCBE-MONOMER
ECOLIWIKI:
 b0933
INTERPRO:
 IPR017875
INTERPRO:
 IPR027417
INTERPRO:
 IPR017871
INTERPRO:
 IPR003593
INTERPRO:
 IPR003439
MODBASE:
 P0AAI1
PFAM:
 PF00005
PRIDE:
 P0AAI1
PRODB:
 PRO_000023995
PROSITE:
 PS50893
PROSITE:
 PS51291
PROSITE:
 PS00211
REFSEQ:
 NP_415453
SMART:
 SM00382
SMR:
 P0AAI1
SWISSMODEL:
 P0AAI1
UNIPROT:
 P0AAI1


Operon      
Name: ssuEADCB         
Operon arrangement:
Transcription unit        Promoter
ssuEADCB


Transcriptional Regulation      
Display Regulation             
Activated by: Cbl, FNR, IHF
Repressed by: CysB, IHF


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1245 (cluster) 991200 forward nd [RS-EPT-CBR] [1]
  promoter TSS_1246 991492 forward nd [RS-EPT-CBR] [1]
  promoter ssuBp3 994141 reverse nd [COMP-AINF] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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