RegulonDB RegulonDB 10.9: Gene Form
   

dtpC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cadA lysU dtpC Lrp terminator terminator yjdLp3 yjdLp3 yjdLp4 yjdLp4 yjdLp1 yjdLp1 yjdLp2 yjdLp2 lysUp1 lysUp1 lysUp2 lysUp2

Gene      
Name: dtpC    Texpresso search in the literature
Synonym(s): ECK4124, EG12469, b4130, yjdL
Genome position(nucleotides): 4354954 <-- 4356411 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.1
External database links:  
ASAP:
ABE-0013524
ECHOBASE:
EB2362
ECOLIHUB:
yjdL
OU-MICROARRAY:
b4130
STRING:
511145.b4130
COLOMBOS: dtpC


Product      
Name: dipeptide/tripeptide:H+ symporter DtpC
Synonym(s): DtpC, YjdL
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 53.055
Isoelectric point: 8.068
Motif(s):
 
Type Positions Sequence
209 -> 229 LPVWSWLVVMLCLAPVFFTLL
388 -> 388 E
141 -> 161 LLYAAGNIGSIAAPIACGLAA
341 -> 361 VWLKFAFGLLLMACGFMLLAF
376 -> 396 VMISGLALMGFAELFIDPVAI

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0015078 - proton transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0015333 - peptide:proton symporter activity
GO:0042937 - tripeptide transmembrane transporter activity
GO:0035673 - oligopeptide transmembrane transporter activity
GO:0071916 - dipeptide transmembrane transporter activity
GO:1904680 - peptide transmembrane transporter activity
biological_process GO:0015031 - protein transport
GO:0006857 - oligopeptide transport
GO:0015833 - peptide transport
GO:0055085 - transmembrane transport
GO:0035443 - tripeptide transmembrane transport
GO:1902600 - proton transmembrane transport
GO:0035442 - dipeptide transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jensen JM., et al., 2012
[2] Kitamura K., et al., 2017
External database links:  
ECOCYC:
YJDL-MONOMER
ECOLIWIKI:
b4130
INTERPRO:
IPR000109
INTERPRO:
IPR036259
INTERPRO:
IPR020846
INTERPRO:
IPR005279
INTERPRO:
IPR018456
MODBASE:
P39276
PANTHER:
PTHR11654
PFAM:
PF00854
PRIDE:
P39276
PROSITE:
PS50850
PROSITE:
PS01023
PROSITE:
PS01022
REFSEQ:
NP_418554
UNIPROT:
P39276


Operon      
Name: dtpC         
Operon arrangement:
Transcription unit        Promoter
dtpC


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yjdLp2 4356413 reverse Similarity to the consensus
Read more >
[ICWHO] [3]
  promoter yjdLp1 4356462 reverse Similarity to the consensus
Read more >
[ICWHO] [3]
  promoter yjdLp4 4356507 reverse Similarity to the consensus
Read more >
[ICWHO] [3]
  promoter yjdLp3 4356517 reverse Similarity to the consensus
Read more >
[ICWHO] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Jensen JM., Ismat F., Szakonyi G., Rahman M., Mirza O., 2012, Probing the putative active site of YjdL: an unusual proton-coupled oligopeptide transporter from E. coli., PLoS One 7(10):e47780

 [2] Kitamura K., Kinsui EZ., Abe F., 2017, Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S., Biochim Biophys Acta 1864(2):393-398

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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