RegulonDB RegulonDB 11.1: Gene Form
   

dppC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dppB dppD dppC dppF TSS_4146 TSS_4146 TSS_4145 TSS_4145 TSS_4144 (cluster) TSS_4144 (cluster) TSS_4143 TSS_4143 TSS_4142 TSS_4142 TSS_4141 TSS_4141 TSS_4140 TSS_4140

Gene      
Name: dppC    Texpresso search in the literature
Synonym(s): ECK3529, EG12626, b3542
Genome position(nucleotides): 3703859 <-- 3704761
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 59.03
External database links:  
ASAP:
 ABE-0011570
CGSC:
 33768
ECHOBASE:
 EB2510
ECOLIHUB:
 dppC
OU-MICROARRAY:
 b3542
STRING:
 511145.b3542
COLOMBOS: dppC


Product      
Name: dipeptide ABC transporter membrane subunit DppC
Synonym(s): DppC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 32.308
Isoelectric point: 6.781
Motif(s):
 
Type Positions Sequence Comment
17 -> 69 TPLQEFWHYFKRNKGAVVGLVYVVIVLFIAIFANWIAPYNPAEQFRDALLAPP
32 -> 52 AVVGLVYVVIVLFIAIFANWI UniProt: Helical.
98 -> 287 ARLSLLVGCLVVVLSLIMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIGNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINIFPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMG UniProt: ABC transmembrane type-1.
102 -> 122 LLVGCLVVVLSLIMGVILGLI UniProt: Helical.
116 -> 299 GVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVAIFGPSIGNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINIFPNCLAPLIVQASLGFSNAILDMAALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMGDGLRDALDPKLK

 
Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0071916 - dipeptide transmembrane transporter activity
biological_process GO:0035351 - heme transmembrane transport
GO:0015031 - protein transport
GO:0015833 - peptide transport
GO:0015886 - heme transport
GO:0042938 - dipeptide transport
GO:0055085 - transmembrane transport
GO:0035442 - dipeptide transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
ALPHAFOLD:
 P0AEG1
DIP:
 DIP-9469N
ECOCYC:
 DPPC-MONOMER
ECOLIWIKI:
 b3542
INTERPRO:
 IPR035906
INTERPRO:
 IPR000515
INTERPRO:
 IPR025966
PFAM:
 PF12911
PFAM:
 PF00528
PRIDE:
 P0AEG1
PRODB:
 PRO_000022475
PROSITE:
 PS50928
REFSEQ:
 NP_417999
UNIPROT:
 P0AEG1


Operon      
Name: dppABCDF         
Operon arrangement:
Transcription unit        Promoter
dppABCDF


Transcriptional Regulation      
Display Regulation             
Activated by: IHF
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4140 3703072 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4141 3703103 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4142 3704129 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4143 3704681 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4144 (cluster) 3704734 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4145 3704861 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4146 3704911 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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