RegulonDB RegulonDB 11.1: Gene Form
   

dppD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yhjV dppF dppD dppC TSS_4144 (cluster) TSS_4144 (cluster) TSS_4143 TSS_4143 TSS_4142 TSS_4142 TSS_4141 TSS_4141 TSS_4140 TSS_4140

Gene      
Name: dppD    Texpresso search in the literature
Synonym(s): ECK3528, EG12627, b3541
Genome position(nucleotides): 3702865 <-- 3703848
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.71
External database links:  
ASAP:
 ABE-0011566
CGSC:
 33765
ECHOBASE:
 EB2511
ECOLIHUB:
 dppD
OU-MICROARRAY:
 b3541
STRING:
 511145.b3541
COLOMBOS: dppD


Product      
Name: dipeptide ABC transporter ATP binding subunit DppD
Synonym(s): DppD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 35.844
Isoelectric point: 6.605
Motif(s):
 
Type Positions Sequence Comment
4 -> 254 LNVDKLSVHFGDESAPFRAVDRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLIDYPGRVMAEKLEFNGQDLQRISEKERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMEAIKVHQGGNKSTRRQRAIDLLNQVGIPDPASRLDVYPHQLSGGMSQRVMIAMAIACRPKLLIADEPTTALDVTIQAQIIELLLELQQKENMALVLITHDLALVAEAAHKIIVMYAGQVVETGDAHAIFHAPRHPYTQALL UniProt: ABC transporter.
24 -> 181 DRISYSVKQGEVVGIVGESGSGKSVSSLAIMGLIDYPGRVMAEKLEFNGQDLQRISEKERRNLVGAEVAMIFQDPMTSLNPCYTVGFQIMEAIKVHQGGNKSTRRQRAIDLLNQVGIPDPASRLDVYPHQLSGGMSQRVMIAMAIACRPKLLIADEPT
40 -> 47 GESGSGKS UniProt: ATP.
154 -> 157 LSGG
173 -> 181 KLLIADEPT

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0005515 - protein binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0015232 - heme transmembrane transporter activity
GO:0071916 - dipeptide transmembrane transporter activity
biological_process GO:0035351 - heme transmembrane transport
GO:0015031 - protein transport
GO:0015833 - peptide transport
GO:0015886 - heme transport
GO:0042938 - dipeptide transport
GO:0035442 - dipeptide transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
ALPHAFOLD:
 P0AAG0
DIP:
 DIP-47940N
ECOCYC:
 DPPD-MONOMER
ECOLIWIKI:
 b3541
INTERPRO:
 IPR017871
INTERPRO:
 IPR027417
INTERPRO:
 IPR013563
INTERPRO:
 IPR003593
INTERPRO:
 IPR003439
MODBASE:
 P0AAG0
PFAM:
 PF08352
PFAM:
 PF00005
PRIDE:
 P0AAG0
PRODB:
 PRO_000022476
PROSITE:
 PS50893
PROSITE:
 PS00211
REFSEQ:
 NP_417998
SMART:
 SM00382
SMR:
 P0AAG0
UNIPROT:
 P0AAG0


Operon      
Name: dppABCDF         
Operon arrangement:
Transcription unit        Promoter
dppABCDF


Transcriptional Regulation      
Display Regulation             
Activated by: IHF
Repressed by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4140 3703072 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4141 3703103 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4142 3704129 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4143 3704681 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4144 (cluster) 3704734 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB