RegulonDB RegulonDB 11.1: Gene Form
   

xapB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

xapB xapR xapA terminator xapBp3 xapBp3 xapBp2 xapBp2 xapBp1 xapBp1 xapRp2 xapRp2 xapRp1 xapRp1

Gene      
Name: xapB    Texpresso search in the literature
Synonym(s): ECK2400, EG13159, b2406
Genome position(nucleotides): 2522729 <-- 2523985
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 48.05
External database links:  
ASAP:
 ABE-0007925
ECHOBASE:
 EB2951
ECOLIHUB:
 xapB
OU-MICROARRAY:
 b2406
STRING:
 511145.b2406
COLOMBOS: xapB


Shine dalgarno      
Sequence: aatgatgcgaCAAGGAaacgatTAT


Product      
Name: xanthosine:H+ symporter XapB
Synonym(s): XapB, XapB xanthosine MFS transporter
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 46.14
Isoelectric point: 8.551
Motif(s):
 
Type Positions Sequence Comment
1 -> 407 MSIAMRLKVMSFLQYFIWGSWLVTLGSYMINTLHFTGANVGMVYSSKGIAAIIMPGIMGIIADKWLRAERAYMLCHLVCAGVLFYAASVTDPDMMFWVMLVNAMAFMPTIALSNSVSYSCLAQAGLDPVTAFPPIRVFGTVGFIVAMWAVSLLHLELSSLQLYIASGASLLLSAYALTLPKIPVAEKKATTSLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFARNPEFADSFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMVAWTLRFGFFAYGDPSTTGFILLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWVGSILSGMAVDYFSVDGVKDWQTIWLVFAGYALFLAVIFFFGFKYNHD
10 -> 30 MSFLQYFIWGSWLVTLGSYMI UniProt: Helical.
42 -> 62 MVYSSKGIAAIIMPGIMGIIA UniProt: Helical.
63 -> 80 DKWLRAERAYMLCHLVCA UniProt: In Ref. 1; CAA52048..
71 -> 91 AYMLCHLVCAGVLFYAASVTD UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
GO:0005337 - nucleoside transmembrane transporter activity
GO:0015553 - xanthosine transmembrane transporter activity
GO:0015213 - uridine transmembrane transporter activity
GO:0015212 - cytidine transmembrane transporter activity
biological_process GO:0055086 - nucleobase-containing small molecule metabolic process
GO:0015858 - nucleoside transport
GO:0055085 - transmembrane transport
GO:0015862 - uridine transport
GO:0071702 - organic substance transport
GO:0015863 - xanthosine transport
GO:1901642 - nucleoside transmembrane transport
GO:0015861 - cytidine transport
Note(s): Note(s): ...[more].
Reference(s): [1] Norholm MH., et al., 2001
External database links:  
ALPHAFOLD:
 P45562
ECOCYC:
 XAPB-MONOMER
ECOLIWIKI:
 b2406
INTERPRO:
 IPR020846
INTERPRO:
 IPR004740
INTERPRO:
 IPR036259
MODBASE:
 P45562
PFAM:
 PF03825
PRIDE:
 P45562
PRODB:
 PRO_000024229
PROSITE:
 PS50850
REFSEQ:
 NP_416901
UNIPROT:
 P45562


Operon      
Name: xapAB         
Operon arrangement:
Transcription unit        Promoter
xapB
xapB
xapB
xapAB
xapAB


Transcriptional Regulation      
Display Regulation             
Activated by: XapR


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Norholm MH., Dandanell G., 2001, Specificity and topology of the Escherichia coli xanthosine permease, a representative of the NHS subfamily of the major facilitator superfamily., J Bacteriol 183(16):4900-4

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