RegulonDB RegulonDB 11.1: Gene Form
   

dgoT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dgoT yidR dgoD cbrA dgoA terminator terminator yidRp2 yidRp2 cbrAp6 cbrAp6

Gene      
Name: dgoT    Texpresso search in the literature
Synonym(s): ECK3683, EG20053, b3691, yidT
Genome position(nucleotides): 3870438 <-- 3871730
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.98
External database links:  
ASAP:
 ABE-0012072
CGSC:
 856
ECHOBASE:
 EB1666
ECOLIHUB:
 dgoT
OU-MICROARRAY:
 b3691
STRING:
 511145.b3691
COLOMBOS: dgoT


Product      
Name: D-galactonate:H+ symporter
Synonym(s): DgoT, YidT
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 47.077
Isoelectric point: 9.692
Motif(s):
 
Type Positions Sequence Comment
18 -> 38 LVMIFITVVICYVDRANLAVA UniProt: Helical.
21 -> 389 IFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVP
31 -> 31 D D → N: loss of function mutation (in K-12 GM4792)
55 -> 75 YVFSAFAWLYTLCQIPGGWFL UniProt: Helical.
85 -> 105 FIAIFGWSVATLFQGFATGLM UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0042881 - D-galactonate transmembrane transporter activity
GO:0015295 - solute:proton symporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0042875 - D-galactonate transmembrane transport
GO:0034194 - D-galactonate catabolic process
GO:0055085 - transmembrane transport
GO:1902600 - proton transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Babbitt PC., et al., 1995
External database links:  
ALPHAFOLD:
 P0AA76
DIP:
 DIP-9436N
ECOCYC:
 YIDT-MONOMER
ECOLIWIKI:
 b3691
INTERPRO:
 IPR011701
INTERPRO:
 IPR020846
INTERPRO:
 IPR036259
MODBASE:
 P0AA76
PDB:
 6E9N
PFAM:
 PF07690
PRIDE:
 P0AA76
PRODB:
 PRO_000022436
PROSITE:
 PS50850
REFSEQ:
 NP_418146
SMR:
 P0AA76
UNIPROT:
 P0AA76


Operon      
Name: dgoRKADT         
Operon arrangement:
Transcription unit        Promoter
dgoRKADT


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: DgoR


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter cbrAp6 3869314 forward nd [COMP-AINF] [2]
  promoter yidRp2 3869412 reverse nd [COMP-AINF] [2]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Babbitt PC., Mrachko GT., Hasson MS., Huisman GW., Kolter R., Ringe D., Petsko GA., Kenyon GL., Gerlt JA., 1995, A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids., Science 267(5201):1159-61

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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