RegulonDB RegulonDB 11.1: Gene Form
   

blr gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ydgJ cnu blr terminator anti-terminator anti-anti-terminator cnup7 cnup7 cnup8 cnup8 cnup10 cnup10 cnup9 cnup9 blrp blrp ydgJp6 ydgJp6 TSS_1902 TSS_1902

Gene      
Name: blr    Texpresso search in the literature
Synonym(s): ECK1620, G0-9561, b4409
Genome position(nucleotides): 1704551 --> 1704676
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 42.86
External database links:  
ASAP:
 ABE-0047212
ECHOBASE:
 EB4132
ECOLIHUB:
 blr
STRING:
 511145.b4409
COLOMBOS: blr


Product      
Name: β-lactam resistance protein
Synonym(s): Blr
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 4.556
Isoelectric point: 6.504
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
Gene Ontology Terms (GO)  
cellular_component GO:0000935 - division septum
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
biological_process GO:0051301 - cell division
GO:0007049 - cell cycle
GO:0046677 - response to antibiotic
GO:0033554 - cellular response to stress
GO:0036460 - cellular response to cell envelope stress
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Hobbs EC., et al., 2010
[2] Wong RS., et al., 2000
External database links:  
ALPHAFOLD:
 P56976
ECOCYC:
 MONOMER0-1561
ECOLIWIKI:
 b4409
PRIDE:
 P56976
PRODB:
 PRO_000022229
REFSEQ:
 YP_025303
UNIPROT:
 P56976


Operon      
Name: blr         
Operon arrangement:
Transcription unit        Promoter
blr


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1902 1704331 reverse nd [RS-EPT-CBR] [3]
  promoter ydgJp6 1704399 reverse nd [COMP-AINF] [4]
  promoter cnup9 1704761 forward nd [COMP-AINF] [4]
  promoter cnup10 1704812 forward nd [COMP-AINF] [4]
  promoter cnup8 1704864 forward nd [COMP-AINF] [4]
  promoter cnup7 1704873 forward nd [COMP-AINF] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Hobbs EC., Astarita JL., Storz G., 2010, Small RNAs and small proteins involved in resistance to cell envelope stress and acid shock in Escherichia coli: analysis of a bar-coded mutant collection., J Bacteriol 192(1):59-67

 [2] Wong RS., McMurry LM., Levy SB., 2000, 'Intergenic' blr gene in Escherichia coli encodes a 41-residue membrane protein affecting intrinsic susceptibility to certain inhibitors of peptidoglycan synthesis., Mol Microbiol 37(2):364-70

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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