RegulonDB RegulonDB 10.9: Gene Form
   

hokC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

insL1 unknown mokC hokC sokC terminator TSS_41 TSS_41 hokCp4 hokCp4 TSS_40 TSS_40 TSS_39 TSS_39

Gene      
Name: hokC    Texpresso search in the literature
Synonym(s): ECK0017, G0-9563, b4412, gef
Genome position(nucleotides): 16751 <-- 16903 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.94
External database links:  
ASAP:
ABE-0047278
ECHOBASE:
EB0368
ECOLIHUB:
hokC
ECOO157CYC:
GEF
STRING:
511145.b4412
COLOMBOS: hokC


Product      
Name: protein HokC
Synonym(s): Gef, HokC, HokC, Gef toxin; interferes with membrane function when in excess
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 5.502
Isoelectric point: 7.424
Motif(s):
 
Type Positions Sequence
6 -> 47 AMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAY
41 -> 41 V
30 -> 30 C
15 -> 15 C
29 -> 29 L

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.6 - protection --> 5.6.3 - cell killing
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0042597 - periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
MONOMER0-1564
ECOLIWIKI:
b4412
ECOO157CYC:
GEF-MONOMER
INTERPRO:
IPR000021
INTERPRO:
IPR018084
PFAM:
PF01848
PRIDE:
P0ACG4
PRINTS:
PR00281
PRODB:
PRO_000022915
PROSITE:
PS00556
REFSEQ:
YP_025292
UNIPROT:
P0ACG4


Operon      
Name: mokC-hokC         
Operon arrangement:
Transcription unit        Promoter
mokC-hokC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_39 15463 forward nd [RS-EPT-CBR] [1]
  promoter TSS_40 15553 forward nd [RS-EPT-CBR] [1]
  promoter hokCp4 16951 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_41 16961 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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