RegulonDB RegulonDB 10.10: Gene Form
   

prpB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

prpR prpC prpB Cra CRP AscG PrpR AscG AscG AscG PrpR AscG PhoB prpBp prpBp prpRp prpRp

Gene      
Name: prpB    Texpresso search in the literature
Synonym(s): ECK0329, G6196, b0331, yahQ
Genome position(nucleotides): 348682 --> 349572 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.12
External database links:  
ASAP:
 ABE-0001138
ECHOBASE:
 EB3370
ECOLIHUB:
 prpB
OU-MICROARRAY:
 b0331
STRING:
 511145.b0331
COLOMBOS: prpB


Product      
Name: 2-methylisocitrate lyase
Synonym(s): PrpB, YahQ
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 32.135
Isoelectric point: 5.397
Motif(s):
 
Type Positions Sequence
2 -> 296 SLHSPGKAFRAALTKENPLQIVGTINANHALLAQRAGYQAIYLSGGGVAAGSLGLPDLGISTLDDVLTDIRRITDVCSLPLLVDADIGFGSSAFNVARTVKSMIKAGAAGLHIEDQVGAKRCGHRPNKAIVSKEEMVDRIRAAVDAKTDPDFVIMARTDALAVEGLDAAIERAQAYVEAGAEMLFPEAITELAMYRQFADAVQVPILANITEFGATPLFTTDELRSAHVAMALYPLSAFRAMNRAAEHVYNVLRQEGTQKSVIDTMQTRNELYESINYYQYEEKLDNLFARSQVK
45 -> 47 SGG
123 -> 124 CG
210 -> 212 NIT
10 -> 250 FRAALTKENPLQIVGTINANHALLAQRAGYQAIYLSGGGVAAGSLGLPDLGISTLDDVLTDIRRITDVCSLPLLVDADIGFGSSAFNVARTVKSMIKAGAAGLHIEDQVGAKRCGHRPNKAIVSKEEMVDRIRAAVDAKTDPDFVIMARTDALAVEGLDAAIERAQAYVEAGAEMLFPEAITELAMYRQFADAVQVPILANITEFGATPLFTTDELRSAHVAMALYPLSAFRAMNRAAEHV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.2 - fatty acids
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0046872 - metal ion binding
GO:0046421 - methylisocitrate lyase activity
GO:0000287 - magnesium ion binding
biological_process GO:0019629 - propionate catabolic process, 2-methylcitrate cycle
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 G6196-MONOMER
ECOLIWIKI:
 b0331
INTERPRO:
 IPR040442
INTERPRO:
 IPR012695
INTERPRO:
 IPR015813
INTERPRO:
 IPR018523
INTERPRO:
 IPR039556
MODBASE:
 P77541
PDB:
 1XG4
PDB:
 1XG3
PDB:
 1OQF
PDB:
 1MZX
PDB:
 1MUM
PFAM:
 PF13714
PRIDE:
 P77541
PRODB:
 PRO_000023606
PROSITE:
 PS00161
REFSEQ:
 NP_414865
SMR:
 P77541
UNIPROT:
 P77541


Operon      
Name: prpBCDE         
Operon arrangement:
Transcription unit        Promoter
prpBCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, PrpR
Repressed by: Cra


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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