RegulonDB RegulonDB 11.1: Gene Form
   

mhpT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mhpT mhpE yaiL mhpF NsrR mhpTp mhpTp TSS_484 TSS_484

Gene      
Name: mhpT    Texpresso search in the literature
Synonym(s): ECK0350, G6206, b0353, yaiK
Genome position(nucleotides): 375459 --> 376670
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 57.43
External database links:  
ASAP:
 ABE-0001213
ECHOBASE:
 EB3078
ECOLIHUB:
 mhpT
OU-MICROARRAY:
 b0353
STRING:
 511145.b0353
COLOMBOS: mhpT


Product      
Name: 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter
Synonym(s): MhpT, YaiK
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 41.551
Isoelectric point: 10.058
Motif(s):
 
Type Positions Sequence Comment
17 -> 37 IGLCFLVALMEGLDLQAAGIA UniProt: Helical; Name=1.
21 -> 301 FLVALMEGLDLQAAGIAAGGIAQAFALDKMQMGWIFSAGILGLLPGALVGGMLADRYGRKRILIGSVALFGLFSLATAIAWDFPSLVFARLMTGVGLGAALPNLIALTSEAAGPRFRGTAVSLMYCGVPIGAALAATLGFAGANLAWQTVFWVGGVVPLILVPLLMRWLPESAVFAGEKQSAPPLRALFAPETATATLLLWLCYFFTLLVVYMLINWLPLLLVEQGFQPSQAAGVMFALQMGAASGTLMLGALMDKLRPVTMSLLIYSGMLASLLALGTVS
27 -> 27 E UniProt: Lack of 3HPP transport activity..
54 -> 74 WIFSAGILGLLPGALVGGMLA UniProt: Helical; Name=2.
75 -> 75 D UniProt: Lack of 3HPP transport activity..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.2 - fatty acids
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0022857 - transmembrane transporter activity
GO:0015540 - 3-hydroxyphenyl propionate:proton symporter activity
biological_process GO:0055085 - transmembrane transport
GO:0042920 - 3-hydroxyphenylpropionic acid transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P77589
ECOCYC:
 MHPT-MONOMER
ECOLIWIKI:
 b0353
INTERPRO:
 IPR020846
INTERPRO:
 IPR011701
INTERPRO:
 IPR005829
INTERPRO:
 IPR036259
MODBASE:
 P77589
PFAM:
 PF07690
PRIDE:
 P77589
PROSITE:
 PS50850
REFSEQ:
 NP_414887
UNIPROT:
 P77589


Operon      
Name: mhpT         
Operon arrangement:
Transcription unit        Promoter
mhpT


Transcriptional Regulation      
Display Regulation             
Repressed by: NsrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_484 374977 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB