RegulonDB

Gene
Name:	iprA
Synonym(s):	ECK0370, G6226, b0375, yaiV
Genome position(nucleotides):	394506 --> 395129
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	39.42
External database links:

ASAP:	ABE-0001290
ECHOBASE:	EB3374
ECOLIHUB:	yaiV
OU-MICROARRAY:	b0375
STRING:	511145.b0375
COLOMBOS:	iprA

Product

Name:

putative DNA-binding transcriptional regulator IprA

Synonym(s):

IprA, YaiV

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

23.956

Isoelectric point:

8.185

Motif(s):

Type	Positions	Sequence	Comment
	138 -> 205	SYEQIRATLLSMIDWNEELRSRIGVMNYIHQRTRISRSVVAEVLAALRKGGYIEMNKGKLVAINRLPS
	163 -> 182	MNYIHQRTRISRSVVAEVLA	UniProt: H-T-H motif.

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	biological_process	GO:0006351 - transcription, DNA-templated GO:0006979 - response to oxidative stress

Note(s):

Note(s): ...[more].

Evidence:

[COMP-AINF-FN-FROM-SEQ] Automated inference of function from sequence
[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Herman A., et al., 2016
[2] Perez-Rueda E., et al., 2004

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

iprA

Operon arrangement:

Transcription unit	Promoter
iprA

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	insFp5	392619	reverse	nd	[COMP-AINF]	[3]
promoter	insFp4	392660	reverse	nd	[COMP-AINF]	[3]
promoter	TSS_488	392979	reverse	nd	[RS-EPT-CBR]	[4]
promoter	yaiVp4	394461	forward	nd	[COMP-AINF]	[3]

Evidence
[COMP-AINF] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Herman A., Serfecz J., Kinnally A., Crosby K., Youngman M., Wykoff D., Wilson JW., 2016, The Bacterial iprA Gene Is Conserved across Enterobacteriaceae, Is Involved in Oxidative Stress Resistance, and Influences Gene Expression in Salmonella enterica Serovar Typhimurium., J Bacteriol 198(16):2166-79
[2] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.