RegulonDB RegulonDB 11.1: Gene Form
   

mdlA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mdlB mdlA decR glnK NtrC TSS_609 TSS_609 glnKp glnKp

Gene      
Name: mdlA    Texpresso search in the literature
Synonym(s): ECK0442, G6248, b0448, mdl
Genome position(nucleotides): 468871 --> 470643
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.03
External database links:  
ASAP:
 ABE-0001555
ECHOBASE:
 EB1579
ECOLIHUB:
 mdlA
OU-MICROARRAY:
 b0448
STRING:
 511145.b0448
COLOMBOS: mdlA


Product      
Name: ABC transporter family protein MdlA
Synonym(s): Mdl, Mdl-N, MdlA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 66.017
Isoelectric point: 6.517
Motif(s):
 
Type Positions Sequence Comment
18 -> 303 YLGAVALLVIIAMLQLVPPKVVGIVVDGVTEQHFTTGQILMWIATMVLIAVVVYLLRYVWRVLLFGASYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARATNDVDRVVFAAGEGVLTLVDSLVMGCAVLIMMSTQISWQLTLFSLLPMPVMAIMIKRNGDALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVARIDARFDPTIYIAIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPMLALAWMFNIVER UniProt: ABC transmembrane type-1.
22 -> 291 VALLVIIAMLQLVPPKVVGIVVDGVTEQHFTTGQILMWIATMVLIAVVVYLLRYVWRVLLFGASYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARATNDVDRVVFAAGEGVLTLVDSLVMGCAVLIMMSTQISWQLTLFSLLPMPVMAIMIKRNGDALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVARIDARFDPTIYIAIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPM
23 -> 43 ALLVIIAMLQLVPPKVVGIVV UniProt: Helical.
53 -> 73 TGQILMWIATMVLIAVVVYLL UniProt: Helical.
134 -> 154 GVLTLVDSLVMGCAVLIMMST UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.am - ABC superfamily, ATP binding and membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0140359 - ABC-type transporter activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0008559 - ABC-type xenobiotic transporter activity
biological_process GO:0055085 - transmembrane transport
GO:0042908 - xenobiotic transport
GO:0046618 - xenobiotic export
Note(s): Note(s): ...[more].
Evidence: [COMP-HINF] Inferred by a human based on computational evidence
Reference(s): [1] Linton KJ., et al., 1998
External database links:  
ALPHAFOLD:
 P77265
DIP:
 DIP-10173N
ECOCYC:
 MDLA-MONOMER
ECOLIWIKI:
 b0448
INTERPRO:
 IPR003593
INTERPRO:
 IPR017871
INTERPRO:
 IPR027417
INTERPRO:
 IPR036640
INTERPRO:
 IPR039421
INTERPRO:
 IPR011527
INTERPRO:
 IPR003439
MODBASE:
 P77265
PANTHER:
 PTHR24221
PFAM:
 PF00005
PFAM:
 PF00664
PRIDE:
 P77265
PRODB:
 PRO_000023175
PROSITE:
 PS50929
PROSITE:
 PS00211
PROSITE:
 PS50893
REFSEQ:
 NP_414982
SMART:
 SM00382
SMR:
 P77265
UNIPROT:
 P77265


Operon      
Name: mdlAB         
Operon arrangement:
Transcription unit        Promoter
mdlAB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_609 472557 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Linton KJ., Higgins CF., 1998, The Escherichia coli ATP-binding cassette (ABC) proteins., Mol Microbiol 28(1):5-13

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB