RegulonDB

Gene
Name:	fiu
Synonym(s):	ECK0794, G6414, b0805, ybiL
Genome position(nucleotides):	839249 <-- 841531
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.83
Reference(s):	[1] Hantke K. 1983
External database links:

ASAP:	ABE-0002749
ECHOBASE:	EB3101
ECOLIHUB:	fiu
OU-MICROARRAY:	b0805
STRING:	511145.b0805
COLOMBOS:	fiu

Product

Name:

iron catecholate outer membrane transporter Fiu

Synonym(s):

Fiu, TonB dependent iron catecholate transporter, YbiL

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

outer membrane

Molecular weight:

81.96

Isoelectric point:

5.728

Motif(s):

Type	Positions	Sequence	Comment
	1 -> 31	MENNRNFPARQFHSLTFFAGLCIGITPVAQA
	32 -> 760	LAAEGQTNADDTLVVEASTPSLYAPQQSADPKFSRPVADTTRTMTVISEQVIKDQGATNLTDALKNVPGVGAFFAGENGNSTTGDAIYMRGADTSNSIYIDGIRDIGSVSRDTFNTEQVEVIKGPSGTDYGRSAPTGSINMISKQPRNDSGIDASASIGSAWFRRGTLDVNQVIGDTTAVRLNVMGEKTHDAGRDKVKNERYGVAPSVAFGLGTANRLYLNYLHVTQHNTPDGGIPTIGLPGYSAPSAGTAALNHSGKVDTHNFYGTDSDYDDSTTDTATMRFEHDINDNTTIRNTTRWSRVKQDYLMTAIMGGASNITQPTSDVNSWTWSRTANTKDVSNKILTNQTNLTSTFYTGSIGHDVSTGVEFTRETQTNYGVNPVTLPAVNIYHPDSSIHPGGLTRNGANANGQTDTFAIYAFDTLQITRDFELNGGIRLDNYHTEYDSATACGGSGRGAITCPTGVAKGSPVTTVDTAKSGNLMNWKAGALYHLTENGNVYINYAVSQQPPGGNNFALAQSGSGNSANRTDFKPQKANTSEIGTKWQVLDKRLLLTAALFRTDIENEVEQNDDGTYSQYGKKRVEGYEISVAGNITPAWQVIGGYTQQKATIKNGKDVAQDGSSSLPYTPEHAFTLWSQYQATDDISVGAGARYIGSMHKGSDGAVGTPAFTEGYWVADAKLGYRVNRNLDFQLNVYNLFDTDYVASINKSGYRYHPGEPRTFLLTANMHF	UniProt: Catecholate siderophore receptor Fiu.
	69 -> 168	ADTTRTMTVISEQVIKDQGATNLTDALKNVPGVGAFFAGENGNSTTGDAIYMRGADTSNSIYIDGIRDIGSVSRDTFNTEQVEVIKGPSGTDYGRSAPTG
	259 -> 758	HNTPDGGIPTIGLPGYSAPSAGTAALNHSGKVDTHNFYGTDSDYDDSTTDTATMRFEHDINDNTTIRNTTRWSRVKQDYLMTAIMGGASNITQPTSDVNSWTWSRTANTKDVSNKILTNQTNLTSTFYTGSIGHDVSTGVEFTRETQTNYGVNPVTLPAVNIYHPDSSIHPGGLTRNGANANGQTDTFAIYAFDTLQITRDFELNGGIRLDNYHTEYDSATACGGSGRGAITCPTGVAKGSPVTTVDTAKSGNLMNWKAGALYHLTENGNVYINYAVSQQPPGGNNFALAQSGSGNSANRTDFKPQKANTSEIGTKWQVLDKRLLLTAALFRTDIENEVEQNDDGTYSQYGKKRVEGYEISVAGNITPAWQVIGGYTQQKATIKNGKDVAQDGSSSLPYTPEHAFTLWSQYQATDDISVGAGARYIGSMHKGSDGAVGTPAFTEGYWVADAKLGYRVNRNLDFQLNVYNLFDTDYVASINKSGYRYHPGEPRTFLLTANM
	743 -> 760	RYHPGEPRTFLLTANMHF	UniProt: TonB C-terminal box; Sequence Annotation Type: short sequence motif.

Classification:

Multifun Terms (GenProtEC)
		4 - transport --> 4.1 - Channel-type Transporters --> 4.1.B - Beta barrel porins (The Outer Membrane Porin (OMP) Functional Superfamily)
		5 - cell processes --> 5.5 - adaptations --> 5.5.7 - Fe aquisition
Gene Ontology Terms (GO)
	cellular_component	GO:0009279 - cell outer membrane GO:0016020 - membrane GO:0016021 - integral component of membrane GO:0045203 - integral component of cell outer membrane GO:1902495 - transmembrane transporter complex
	molecular_function	GO:0038023 - signaling receptor activity GO:0015344 - siderophore uptake transmembrane transporter activity
	biological_process	GO:0006811 - ion transport GO:0055072 - iron ion homeostasis GO:0015891 - siderophore transport GO:0042884 - microcin transport GO:0033214 - siderophore-dependent iron import into cell GO:0044718 - siderophore transmembrane transport

Note(s):

Note(s): ...[more].

Reference(s):

[2] Critchley IA., et al., 1991
[3] Hantke K. 1987
[4] Mercado G., et al., 2008
[5] Mollmann U., et al., 1998
[6] Muela A., et al., 2008
[7] Muller SI., et al., 2009
[8] Reissbrodt R., et al., 1997

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PANTHER:

PANTHER:

PDB:

PDB:

PDB:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	Fur

Reference(s)
[1] Hantke K., 1983, Identification of an iron uptake system specific for coprogen and rhodotorulic acid in Escherichia coli K12., Mol Gen Genet 191(2):301-6
[2] Critchley IA., Basker MJ., Edmondson RA., Knott SJ., 1991, Uptake of a catecholic cephalosporin by the iron transport system of Escherichia coli., J Antimicrob Chemother 28(3):377-88
[3] Hantke K., 1987, Selection procedure for deregulated iron transport mutants (fur) in Escherichia coli K 12: fur not only affects iron metabolism., Mol Gen Genet 210(1):135-9
[4] Mercado G., Tello M., Marin M., Monasterio O., Lagos R., 2008, The production in vivo of microcin E492 with antibacterial activity depends on salmochelin and EntF., J Bacteriol 190(15):5464-71
[5] Mollmann U., Ghosh A., Dolence EK., Dolence JA., Ghosh M., Miller MJ., Reissbrodt R., 1998, Selective growth promotion and growth inhibition of gram-negative and gram-positive bacteria by synthetic siderophore-beta-lactam conjugates., Biometals 11(1):1-12
[6] Muela A., Seco C., Camafeita E., Arana I., Orruno M., Lopez JA., Barcina I., 2008, Changes in Escherichia coli outer membrane subproteome under environmental conditions inducing the viable but nonculturable state., FEMS Microbiol Ecol 64(1):28-36
[7] Muller SI., Valdebenito M., Hantke K., 2009, Salmochelin, the long-overlooked catecholate siderophore of Salmonella., Biometals 22(4):691-5
[8] Reissbrodt R., Ramiandrasoa F., Bricard L., Kunesch G., 1997, Siderophore activity of chemically synthesized dihydroxybenzoyl derivatives of spermidines and cystamide., Biometals 10(2):95-103
[9] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78