RegulonDB RegulonDB 11.2: Gene Form
   

lysO gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hcp lysO aqpZ ArgR ArgR NarL NarP NarL NarP FNR NsrR ybjEp5 ybjEp5 ybjEp3 ybjEp3 lysOp lysOp hcpp2 hcpp2 hcpp1 hcpp1 TSS_1024 TSS_1024 hcrp3 hcrp3

Gene      
Name: lysO    Texpresso search in the literature
Synonym(s): ECK0865, G6458, b0874, ybjE
Genome position(nucleotides): 913958 <-- 914857
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 48.22
External database links:  
ASAP:
 ABE-0002966
ECHOBASE:
 EB3200
ECOLIHUB:
 ybjE
OU-MICROARRAY:
 b0874
STRING:
 511145.b0874
COLOMBOS: lysO


Product      
Name: L-lysine/thialysine exporter
Synonym(s): LysO, YbjE
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 32.34
Isoelectric point: 9.224
Motif(s):
 
Type Positions Sequence Comment
1 -> 21 MFSGLLIILVPLIVGYLIPLR UniProt: Helical.
31 -> 51 QLLSWMVYLILFFMGISLAFL UniProt: Helical.
58 -> 78 LLAILHYSAVSITVILLCNIA UniProt: Helical.
109 -> 129 LKLCGVVVIGFAIGLSGLAFL UniProt: Helical.
113 -> 297 GVVVIGFAIGLSGLAFLQHATEASEYTLILLLFLVGIQLRNNGMTLKQIVLNRRGMIVAVVVVVSSLIGGLINAFILDLPINTALAMASGFGWYSLSGILLTESFGPVIGSAAFFNDLARELIAIMLIPGLIRRSRSTALGLCGATSMDFTLPVLQRTGGLDMVPAAIVHGFILSLLVPILIAFF

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.9.B - Putative uncharacterized transport protein
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015661 - L-lysine efflux transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:1903401 - L-lysine transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P75826
DIP:
 DIP-11447N
ECOCYC:
 G6458-MONOMER
ECOLIWIKI:
 b0874
INTERPRO:
 IPR005642
PANTHER:
 PTHR35804
PFAM:
 PF03956
PRIDE:
 P75826
REFSEQ:
 NP_415395
SMR:
 P75826
UNIPROT:
 P75826


Operon      
Name: lysO         
Operon arrangement:
Transcription unit        Promoter
lysO


Transcriptional Regulation      
Display Regulation             
Repressed by: ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter hcrp3 912200 reverse nd [COMP-AINF] [1]
  promoter TSS_1024 912408 reverse nd [RS-EPT-CBR] [2]
  promoter ybjEp3 914901 reverse nd [COMP-AINF] [1]
  promoter ybjEp5 915077 reverse nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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