RegulonDB RegulonDB 11.1: Gene Form
   

torS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

torS yccM torT torR terminator torTp2 torTp2 torTp1 torTp1 torTp7 torTp7 torSp5 torSp5 TSS_1311 TSS_1311

Gene      
Name: torS    Texpresso search in the literature
Synonym(s): ECK0984, G6514, b0993, yccI
Genome position(nucleotides): 1053434 <-- 1056178
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.77
Reference(s): [1] Jourlin C., et al., 1996
External database links:  
ASAP:
 ABE-0003354
ECHOBASE:
 EB2501
ECOLIHUB:
 torS
OU-MICROARRAY:
 b0993
STRING:
 511145.b0993
COLOMBOS: torS


Product      
Name: sensor histidine kinase TorS
Synonym(s): TorS, YccI
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space,inner membrane
Molecular weight: 101.024
Isoelectric point: 5.258
Motif(s):
 
Type Positions Sequence Comment
9 -> 29 LWMGFALMALLTLTSTLVGWY UniProt: Helical.
295 -> 297 AQF UniProt: In torS726; constitutively active
333 -> 353 LLLLGMVSLCALILILWRVVY UniProt: Helical.
352 -> 403 VYRSVTRPLAEQTQALQRLLDGDIDSPFPETAGVRELDTIGRLMDAFRSNVH
354 -> 407 RSVTRPLAEQTQALQRLLDGDIDSPFPETAGVRELDTIGRLMDAFRSNVHALNR UniProt: HAMP.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0016740 - transferase activity
GO:0016772 - transferase activity, transferring phosphorus-containing groups
GO:0016301 - kinase activity
GO:0004721 - phosphoprotein phosphatase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0000155 - phosphorelay sensor kinase activity
GO:0004673 - protein histidine kinase activity
GO:0042802 - identical protein binding
GO:0042803 - protein homodimerization activity
biological_process GO:0009061 - anaerobic respiration
GO:0006470 - protein dephosphorylation
GO:0016310 - phosphorylation
GO:0000160 - phosphorelay signal transduction system
GO:0007165 - signal transduction
GO:0046777 - protein autophosphorylation
GO:0018106 - peptidyl-histidine phosphorylation
GO:0071310 - cellular response to organic substance
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Jourlin C., et al., 1996
[2] Moore JO., et al., 2009
External database links:  
ALPHAFOLD:
 P39453
DIP:
 DIP-11017N
ECOCYC:
 TORS-MONOMER
ECOLIWIKI:
 b0993
INTERPRO:
 IPR037952
INTERPRO:
 IPR036890
INTERPRO:
 IPR036641
INTERPRO:
 IPR036097
INTERPRO:
 IPR014302
INTERPRO:
 IPR011006
INTERPRO:
 IPR008207
INTERPRO:
 IPR038188
INTERPRO:
 IPR003660
INTERPRO:
 IPR003594
INTERPRO:
 IPR003661
INTERPRO:
 IPR001789
INTERPRO:
 IPR004358
INTERPRO:
 IPR005467
MODBASE:
 P39453
PDB:
 3I9W
PFAM:
 PF02518
PFAM:
 PF01627
PFAM:
 PF00672
PFAM:
 PF00512
PFAM:
 PF00072
PRIDE:
 P39453
PRINTS:
 PR00344
PRODB:
 PRO_000024090
PROSITE:
 PS50110
PROSITE:
 PS50885
PROSITE:
 PS50894
PROSITE:
 PS50109
REFSEQ:
 NP_415513
SMART:
 SM00448
SMART:
 SM00073
SMART:
 SM00304
SMART:
 SM00387
SMART:
 SM00388
SMR:
 P39453
UNIPROT:
 P39453


Operon      
Name: torS         
Operon arrangement:
Transcription unit        Promoter
torS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1311 1053395 reverse nd [RS-EPT-CBR] [3]
  promoter torSp5 1056182 reverse nd [COMP-AINF] [4]
  promoter torTp7 1056207 forward nd [COMP-AINF] [4]
  promoter torTp1 1056220 forward nd [COMP-AINF] [4]
  promoter torTp2 1056222 forward nd [COMP-AINF] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Jourlin C., Bengrine A., Chippaux M., Mejean V., 1996, An unorthodox sensor protein (TorS) mediates the induction of the tor structural genes in response to trimethylamine N-oxide in Escherichia coli., Mol Microbiol 20(6):1297-306

 [2] Moore JO., Hendrickson WA., 2009, Structural analysis of sensor domains from the TMAO-responsive histidine kinase receptor TorS., Structure 17(9):1195-204

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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