RegulonDB

Gene
Name:	clsC
Synonym(s):	ECK1032, G6551, b1046, ymdC
Genome position(nucleotides):	1106355 --> 1107776 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.7
External database links:

ASAP:	ABE-0003551
ECHOBASE:	EB3634
ECOLIHUB:	ymdC
OU-MICROARRAY:	b1046
STRING:	511145.b1046
COLOMBOS:	clsC

Product

Name:

cardiolipin synthase C

Synonym(s):

ClsC, YmdC, cardiolipin synthase 3

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

53.666

Isoelectric point:

9.458

Motif(s):

Type	Positions	Sequence
	125 -> 152	LNRRMHNKSFTVDGVVTLVGGRNIGDAY
	274 -> 417	IMGSPSERIDIISSYFVPTRAGVAQLLRMVRKGVKIAILTNSLAANDVAVVHAGYARWRKKLLRYGVELYELKPTREQSSTLHDRGITGNSGASLHAKTFSIDGKTVFIGSFNFDPRSTLLNTEMGFVIESETLAQLIDKRFIQ
	369 -> 369	H
	130 -> 130	H
	364 -> 391	SGASLHAKTFSIDGKTVFIGSFNFDPRS

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.1 - phospholipid
Gene Ontology Terms (GO)
	cellular_component	GO:0005886 - plasma membrane
	molecular_function	GO:0003824 - catalytic activity GO:0016740 - transferase activity GO:0016780 - phosphotransferase activity, for other substituted phosphate groups GO:0090483 - phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity
	biological_process	GO:0006629 - lipid metabolic process GO:0008654 - phospholipid biosynthetic process GO:0032049 - cardiolipin biosynthetic process

Note(s):

Note(s): ...[more].

Reference(s):

[1] Douglass MV., et al., 2021
[2] Qiu N., et al., 2019
[3] Rathmann C., et al., 2017

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PROSITE:

REFSEQ:

SMART:

UNIPROT:

Reference(s)
[1] Douglass MV., Cleon F., Trent MS., 2021, Cardiolipin aids in lipopolysaccharide transport to the gram-negative outer membrane., Proc Natl Acad Sci U S A 118(15)
[2] Qiu N., Misra R., 2019, Overcoming Iron Deficiency of an Escherichia coli tonB Mutant by Increasing Outer Membrane Permeability., J Bacteriol 201(17)
[3] Rathmann C., Schlosser AS., Schiller J., Bogdanov M., Bruser T., 2017, Tat transport in Escherichia coli requires zwitterionic phosphatidylethanolamine but no specific negatively charged phospholipid., FEBS Lett 591(18):2848-2858