RegulonDB

RegulonDB RegulonDB 11.1: Gene Form

bluR gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	bluR
Synonym(s):	ECK1149, G6602, b1162, ycgE
Genome position(nucleotides):	1213328 <-- 1214059
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	48.77
External database links:

ASAP:	ABE-0003900
ECHOBASE:	EB3645
ECOLIHUB:	ycgE
OU-MICROARRAY:	b1162
STRING:	511145.b1162
COLOMBOS:	bluR

Product

Name:

DNA-binding transcriptional repressor BluR

Synonym(s):

BluR, YcgE

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

MerR

Cellular location:

cytosol

Molecular weight:

28.264

Isoelectric point:

8.448

Motif(s):

Type	Positions	Sequence	Comment
	3 -> 72	YYSIGDVAERCGINPVTLRAWQRRYGLLKPQRSEGGHRLFDEEDIQRIEEIKRWISNGVPVGKVKALLET	UniProt: HTH merR-type.
	4 -> 71	YSIGDVAERCGINPVTLRAWQRRYGLLKPQRSEGGHRLFDEEDIQRIEEIKRWISNGVPVGKVKALLE
	6 -> 25	IGDVAERCGINPVTLRAWQR	UniProt: H-T-H motif.

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0005515 - protein binding GO:0003700 - DNA-binding transcription factor activity
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0045892 - negative regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[COMP-HINF-FN-FROM-SEQ] Human inference of function from sequence
[EXP-IDA-PURIFIED-PROTEIN] Assay of protein purified to homogeneity
[EXP-IEP] Inferred from expression pattern

Reference(s):

[1] Perez-Rueda E., et al., 2004
[2] Tschowri N., et al., 2009

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

bluR

Operon arrangement:

Transcription unit	Promoter
bluR	bluRp

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	ycgXp5	1213212	reverse	nd	[COMP-AINF]	[3]
promoter	TSS_1498	1213280	reverse	nd	[RS-EPT-CBR]	[4]
promoter	ycgXp4	1213284	reverse	nd	[COMP-AINF]	[3]

Evidence
[COMP-AINF] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50
[2] Tschowri N., Busse S., Hengge R., 2009, The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light response of Escherichia coli., Genes Dev 23(4):522-34
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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