RegulonDB

RegulonDB RegulonDB 11.1: Gene Form

dosP gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	dosP
Synonym(s):	ECK1483, G6783, b1489, dos, pdeO, yddU
Genome position(nucleotides):	1563334 <-- 1565733
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.21
External database links:

ASAP:	ABE-0004963
ECHOBASE:	EB3553
ECOLIHUB:	dosP
ECOO157CYC:	Z2221
ECOO157CYC:	Z2220
OU-MICROARRAY:	b1489
STRING:	511145.b1489
COLOMBOS:	dosP

Product

Name:

oxygen-sensing c-di-GMP phosphodiesterase DosP

Synonym(s):

Dos, DosP, PdeO, YddU, c-di-GMP phosphodiesterase, heme-regulated

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

90.26

Isoelectric point:

5.245

Motif(s):

Type	Positions	Sequence	Comment
	10 -> 81	ADGIFFPALEQNMMGAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDMLIPRDLRPAHPEYIRHNREGGK	UniProt: PAS 1.
	24 -> 124	GAVLINENDEVMFFNPAAEKLWGYKREEVIGNNIDMLIPRDLRPAHPEYIRHNREGGKARVEGMSRELQLEKKDGSKIWTRFALSKVSAEGKVYYLALVRD
	69 -> 69	H	UniProt: Loss of heme binding..
	75 -> 75	H	UniProt: No loss of heme binding..
	87 -> 87	M	UniProt: Ferrous heme iron changes from an exclusively hexacoordinate low-spin form to an exclusively pentacoordinate high-spin form. Ferric heme iron remains hexacoordinate but becomes a mixture of high and low spin. Increases c-di-GMP PDE activity 7-fold in absence of O(2), CO or NO, no additional increase upon addition of gases (M-A only)..

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		5 - cell processes --> 5.5 - adaptations
Gene Ontology Terms (GO)
	cellular_component	GO:0005886 - plasma membrane
	molecular_function	GO:0005515 - protein binding GO:0016787 - hydrolase activity GO:0046872 - metal ion binding GO:0000287 - magnesium ion binding GO:0020037 - heme binding GO:0042803 - protein homodimerization activity GO:0071111 - cyclic-guanylate-specific phosphodiesterase activity GO:0019826 - oxygen sensor activity
	biological_process	GO:0050896 - response to stimulus GO:0070482 - response to oxygen levels

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

ECOO157CYC:

ECOO157CYC:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PFAM:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMART:

SMART:

SMART:

SMR:

UNIPROT:

Operon

Name:

dosCP

Operon arrangement:

Transcription unit	Promoter
dosCP

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	dosPp3	1565743		reverse	nd	[COMP-AINF]	[1]

Evidence
[COMP-AINF] Inferred computationally without human oversight

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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