RegulonDB RegulonDB 10.8: Gene Form
   

tcyP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

tcyP ydjO ydjM terminator TSS_2045 (cluster) TSS_2045 (cluster) tcyPp tcyPp

Gene      
Name: tcyP    Texpresso search in the literature
Synonym(s): ECK1727, G6934, b1729, ydjN
Genome position(nucleotides): 1810934 --> 1812325 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.44
External database links:  
ASAP:
 ABE-0005771
ECHOBASE:
 EB3746
OU-MICROARRAY:
 b1729
PortEco:
 ydjN
STRING:
 511145.b1729
COLOMBOS: tcyP


Product      
Name: cystine/sulfocysteine:cation symporter
Synonym(s): TcyP, YdjN
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 48.662
Isoelectric point: 9.502
Motif(s):
 
Type Positions Sequence
33 -> 53 VLVGLVMGVVFGLALHTIYGS
185 -> 205 TSIISVVIFAAFLGVAALKLL
347 -> 367 AGLYPAMLAVMVAPTVGINPL
29 -> 443 LAKKVLVGLVMGVVFGLALHTIYGSDSQVLKDSVQWFNIVGNGYVQLLQMIVMPLVFASILSAVARLHNASQLGKISFLTIGTLLFTTLIAALVGVLVTNLFGLTAEGLVQGGAETARLNAIESNYVGKVSDLSVPQLVLSFIPKNPFADLTGANPTSIISVVIFAAFLGVAALKLLKDDAPKGERVLAAIDTLQSWVMKLVRLVMQLTPYGVLALMTKVVAGSNLQDIIKLGSFVVASYLGLLIMFAVHGILLGINGVSPLKYFRKVWPVLTFAFTSRSSAASIPLNVEAQTRRLGVPESIASFAASFGATIGQNGCAGLYPAMLAVMVAPTVGINPLDPMWIATLVGIVTVSSAGVAGVGGGATFAALIVLPAMGLPVTLVALLISVEPLIDMGRTALNVSGSMTAGTLTSQW
370 -> 390 MWIATLVGIVTVSSAGVAGVG

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015293 - symporter activity
GO:0022857 - transmembrane transporter activity
GO:0000099 - sulfur amino acid transmembrane transporter activity
GO:0005416 - amino acid:cation symporter activity
GO:0015184 - L-cystine transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:0000101 - sulfur amino acid transport
GO:0006791 - sulfur utilization
GO:0055085 - transmembrane transport
GO:0003333 - amino acid transmembrane transport
GO:0015811 - L-cystine transport
Note(s): Note(s): ...[more].
Reference(s): [1] Burguiere P., et al., 2004
External database links:  
DIP:
 DIP-11776N
ECOCYC:
 G6934-MONOMER
ECOLIWIKI:
 b1729
INTERPRO:
 IPR036458
INTERPRO:
 IPR001991
PANTHER:
 PTHR11958
PFAM:
 PF00375
PRIDE:
 P77529
PRINTS:
 PR00173
PROSITE:
 PS00714
PROSITE:
 PS00713
REFSEQ:
 NP_416243
SMR:
 P77529
UNIPROT:
 P77529


Operon      
Name: tcyP         
Operon arrangement:
Transcription unit        Promoter
tcyP


Transcriptional Regulation      
Display Regulation             
Activated by: CysB


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2045 (cluster) 1811112 forward For this promoter, there
Read more > 		[RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Burguiere P., Auger S., Hullo MF., Danchin A., Martin-Verstraete I., 2004, Three different systems participate in L-cystine uptake in Bacillus subtilis., J Bacteriol 186(15):4875-84

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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