RegulonDB

Gene
Name:	cho
Synonym(s):	ECK1739, G6937, b1741, ydjQ
Genome position(nucleotides):	1823515 --> 1824402 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.58
External database links:

ASAP:	ABE-0005807
ECHOBASE:	EB3749
ECOLIHUB:	cho
OU-MICROARRAY:	b1741
STRING:	511145.b1741
COLOMBOS:	cho

Product

Name:

excinuclease Cho

Synonym(s):

Cho, YdjQ, endonuclease of nucleotide excision repair, sosD

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

33.739

Isoelectric point:

8.946

Motif(s):

Type	Positions	Sequence
	33 -> 108	TRPGVYLFHGESDTMPLYIGKSVNIRSRVLSHLRTPDEAAMLRQSRRISWICTAGEIGALLLEARLIKEQQPLFNK

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
		5 - cell processes --> 5.6 - protection
		5 - cell processes --> 5.8 - SOS response
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol GO:0009380 - excinuclease repair complex
	molecular_function	GO:0004518 - nuclease activity GO:0005515 - protein binding GO:0016787 - hydrolase activity GO:0004520 - endodeoxyribonuclease activity
	biological_process	GO:0006281 - DNA repair GO:0006974 - cellular response to DNA damage stimulus GO:0009432 - SOS response GO:0033683 - nucleotide-excision repair, DNA incision

Note(s):

Note(s): ...[more].

Evidence:

[APPH] Assay of protein purified to homogeneity

Reference(s):

[1] Moolenaar GF., et al., 2002

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

MODBASE:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMART:

UNIPROT:

Operon

Name:

cho

Operon arrangement:

Transcription unit	Promoter
cho	chop

Transcriptional Regulation
	Display Regulation
Repressed by:	LexA

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_2052	1822732		forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Moolenaar GF., van Rossum-Fikkert S., van Kesteren M., Goosen N., 2002, Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair., Proc Natl Acad Sci U S A 99(3):1467-72
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Moolenaar GF., van Rossum-Fikkert S., van Kesteren M., Goosen N., 2002, Cho, a second endonuclease involved in Escherichia coli nucleotide excision repair., Proc Natl Acad Sci U S A 99(3):1467-72

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.