RegulonDB RegulonDB 11.1: Gene Form
   

astD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

astD astB astC astA astE astEp3 astEp3

Gene      
Name: astD    Texpresso search in the literature
Synonym(s): ECK1744, G6942, b1746, ydjU
Genome position(nucleotides): 1828256 <-- 1829734
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 58.08
External database links:  
ASAP:
 ABE-0005820
ECHOBASE:
 EB3753
ECOLIHUB:
 astD
OU-MICROARRAY:
 b1746
STRING:
 511145.b1746
COLOMBOS: astD


Product      
Name: aldehyde dehydrogenase
Synonym(s): AstD, YdjU
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 53.026
Isoelectric point: 5.868
Motif(s):
 
Type Positions Sequence Comment
9 -> 458 WITGQGASRVKRNPVSGEVLWQGNDADAAQVEQACRAARAAFPRWARLSFAERHAVVERFAALLESNKAELTAIIARETGKPRWEAATEVTAMINKIAISIKAYHVRTGEQRSEMPDGAASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTIIFKPSELTPWSGEAVMRLWQQAGLPPGVLNLVQGGRETGQALSALEDLDGLLFTGSANTGYQLHRQLSGQPEKILALEMGGNNPLIIDEVADIDAAVHLTIQSAFVTAGQRCTCARRLLLKSGAQGDAFLARLVAVSQRLTPGNWDDEPQPFIGGLISEQAAQQVVTAWQQLEAMGGRPLLAPRLLQAGTSLLTPGIIEMTGVAGVPDEEVFGPLLRVWRYDTFDEAIRMANNTRFGLSCGLVSPEREKFDQLLLEARAGIVNWNKPLTGAASTAPFGGIGASGNHRPSAWYA
220 -> 225 GSANTG UniProt: NAD.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016491 - oxidoreductase activity
GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004777 - succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0043824 - succinylglutamate-semialdehyde dehydrogenase activity
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
biological_process GO:0006525 - arginine metabolic process
GO:0006527 - arginine catabolic process
GO:0019544 - arginine catabolic process to glutamate
GO:0019545 - arginine catabolic process to succinate
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P76217
DIP:
 DIP-9186N
ECOCYC:
 SUCCGLUALDDEHYD-MONOMER
ECOLIWIKI:
 b1746
INTERPRO:
 IPR016162
INTERPRO:
 IPR016163
INTERPRO:
 IPR017649
INTERPRO:
 IPR015590
INTERPRO:
 IPR029510
INTERPRO:
 IPR016160
INTERPRO:
 IPR016161
MODBASE:
 P76217
PANTHER:
 PTHR11699:SF197
PFAM:
 PF00171
PRIDE:
 P76217
PRODB:
 PRO_000022178
PROSITE:
 PS00687
PROSITE:
 PS00070
REFSEQ:
 NP_416260
SMR:
 P76217
UNIPROT:
 P76217


Operon      
Name: astCADBE         
Operon arrangement:
Transcription unit        Promoter
astCADBE
astCADBE
astCADBE


Transcriptional Regulation      
Display Regulation             
Activated by: NtrC, ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter astEp3 1827069 reverse nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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