RegulonDB RegulonDB 11.1: Gene Form
   

astA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

astD astB astC astA xthA astE NtrC NtrC NtrC ArgR ArgR ArgR ArgR terminator anti-terminator anti-anti-terminator ydjXp5 ydjXp5 xthAp xthAp astCp2 astCp2 astCp3 astCp3 astCp1 astCp1 astEp3 astEp3

Gene      
Name: astA    Texpresso search in the literature
Synonym(s): ECK1745, G6943, b1747, ydjV
Genome position(nucleotides): 1829731 <-- 1830765
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.04
External database links:  
ASAP:
 ABE-0005822
ECHOBASE:
 EB3754
ECOLIHUB:
 astA
OU-MICROARRAY:
 b1747
STRING:
 511145.b1747
COLOMBOS: astA


Product      
Name: arginine N-succinyltransferase
Synonym(s): AstA, YdjV
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 38.456
Isoelectric point: 6.427
Motif(s):
 
Type Positions Sequence Comment
1 -> 335 MMVIRPVERSDVSALMQLASKTGGGLTSLPANEATLSARIERAIKTWQGELPKSEQGYVFVLEDSETGTVAGICAIEVAVGLNDPWYNYRVGTLVHASKELNVYNALPTLFLSNDHTGSSELCTLFLDPDWRKEGNGYLLSKSRFMFMAAFRDKFNDKVVAEMRGVIDEHGYSPFWQSLGKRFFSMDFSRADFLCGTGQKAFIAELMPKHPIYTHFLSQEAQDVIGQVHPQTAPARAVLEKEGFRYRNYIDIFDGGPTLECDIDRVRAIRKSRLVEVAEGQPAQGDFPACLVANENYHHFRVVLVRTDPATERLILTAAQLDALKCHAGDRVRLV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016740 - transferase activity
GO:0016746 - acyltransferase activity
GO:0008791 - arginine N-succinyltransferase activity
biological_process GO:0006525 - arginine metabolic process
GO:0006527 - arginine catabolic process
GO:0019544 - arginine catabolic process to glutamate
GO:0019545 - arginine catabolic process to succinate
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0AE37
ECOCYC:
 ARGSUCCTRAN-MONOMER
ECOLIWIKI:
 b1747
INTERPRO:
 IPR016181
INTERPRO:
 IPR007041
INTERPRO:
 IPR017650
PFAM:
 PF04958
PRIDE:
 P0AE37
PRODB:
 PRO_000022175
REFSEQ:
 NP_416261
SMR:
 P0AE37
UNIPROT:
 P0AE37


Operon      
Name: astCADBE         
Operon arrangement:
Transcription unit        Promoter
astCADBE
astCADBE
astCADBE


Transcriptional Regulation      
Display Regulation             
Activated by: NtrC, ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter astEp3 1827069 reverse nd [COMP-AINF] [1]
  promoter ydjXp5 1833217 forward nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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