RegulonDB RegulonDB 11.1: Gene Form
   

astC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

astD astC astA xthA astB NtrC NtrC NtrC ArgR ArgR ArgR ArgR terminator anti-terminator anti-anti-terminator ydjXp5 ydjXp5 xthAp xthAp astCp2 astCp2 astCp3 astCp3 astCp1 astCp1

Gene      
Name: astC    Texpresso search in the literature
Synonym(s): ECK1746, G6944, argM, b1748, cstC, ydjW
Genome position(nucleotides): 1830762 <-- 1831982
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.04
External database links:  
ASAP:
 ABE-0005824
ECHOBASE:
 EB3755
ECOLIHUB:
 astC
NCBI-GENE:
 946255
OU-MICROARRAY:
 b1748
STRING:
 511145.b1748
COLOMBOS: astC


Product      
Name: succinylornithine transaminase
Synonym(s): ArgM, AstC, CstC, YdjW
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 43.665
Isoelectric point: 6.326
Motif(s):
 
Type Positions Sequence Comment
22 -> 396 PFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALIDDSTCAVIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHYGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNTINHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAA
361 -> 361 A UniProt: In Ref. 1; AAB51148..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0008483 - transaminase activity
GO:0030170 - pyridoxal phosphate binding
GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0042802 - identical protein binding
GO:0043825 - succinylornithine transaminase activity
biological_process GO:0006520 - cellular amino acid metabolic process
GO:0006525 - arginine metabolic process
GO:0006527 - arginine catabolic process
GO:0019544 - arginine catabolic process to glutamate
GO:0042450 - arginine biosynthetic process via ornithine
GO:0006593 - ornithine catabolic process
GO:0019545 - arginine catabolic process to succinate
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P77581
DIP:
 DIP-9145N
ECOCYC:
 SUCCORNTRANSAM-MONOMER
ECOLIWIKI:
 b1748
INTERPRO:
 IPR005814
INTERPRO:
 IPR026330
INTERPRO:
 IPR015421
INTERPRO:
 IPR015422
INTERPRO:
 IPR015424
INTERPRO:
 IPR017652
INTERPRO:
 IPR004636
MODBASE:
 P77581
PDB:
 4ADB
PDB:
 4ADC
PDB:
 4ADD
PDB:
 4ADE
PFAM:
 PF00202
PRIDE:
 P77581
PRODB:
 PRO_000022177
PROSITE:
 PS00600
REFSEQ:
 NP_416262
SMR:
 P77581
SWISSMODEL:
 P77581
UNIPROT:
 P77581


Operon      
Name: astCADBE         
Operon arrangement:
Transcription unit        Promoter
astCADBE
astCADBE
astCADBE


Transcriptional Regulation      
Display Regulation             
Activated by: NtrC, ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ydjXp5 1833217 forward nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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