RegulonDB

Gene
Name:	cbtA
Synonym(s):	ECK1998, G7085, b2005, yeeV
Genome position(nucleotides):	2077569 --> 2077943 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.07
External database links:

ASAP:	ABE-0006659
ECHOBASE:	EB3170
ECOLIHUB:	yeeV
OU-MICROARRAY:	b2005
STRING:	511145.b2005
COLOMBOS:	cbtA

Product

Name:

CP4-44 prophage; cytoskeleton-binding toxin CbtA

Synonym(s):

CP4-44 prophage; toxin of the CbtA-CbeA toxin-antitoxin system, CbtA, YeeV

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

13.899

Isoelectric point:

8.214

Motif(s):

Type	Positions	Sequence
	1 -> 15	MKTLPVLPGQAASSR
	15 -> 15	R
	65 -> 65	F
	74 -> 124	RTDQPGFSACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Classification:

Multifun Terms (GenProtEC)
		5 - cell processes --> 5.6 - protection --> 5.6.3 - cell killing
		8 - extrachromosomal --> 8.1 - prophage genes and phage related functions
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0005515 - protein binding GO:0008092 - cytoskeletal protein binding
	biological_process	GO:0051494 - negative regulation of cytoskeleton organization GO:0008360 - regulation of cell shape GO:0001896 - autolysis GO:2000245 - negative regulation of FtsZ-dependent cytokinesis

Note(s):

Note(s): ...[more].

Evidence:

[IDA] Inferred from direct assay
[IE] Inferred from experiment

Reference(s):

[1] Brown JM., et al., 2003
[2] Tan Q., et al., 2011

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PFAM:

PRIDE:

REFSEQ:

UNIPROT:

Reference(s)
[1] Brown JM., Shaw KJ., 2003, A novel family of Escherichia coli toxin-antitoxin gene pairs., J Bacteriol 185(22):6600-8
[2] Tan Q., Awano N., Inouye M., 2011, YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB., Mol Microbiol 79(1):109-18