RegulonDB

Gene
Name:	rseC
Synonym(s):	ECK2568, G7347, b2570
Genome position(nucleotides):	2707322 <-- 2707801
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	54.79
External database links:

ASAP:	ABE-0008457
ECHOBASE:	EB2970
ECOLIHUB:	rseC
OU-MICROARRAY:	b2570
STRING:	511145.b2570
COLOMBOS:	rseC

Product

Name:

protein RseC

Synonym(s):

RseC, SoxR and sigma;^E factor regulatory protein RseC

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

16.639

Isoelectric point:

7.044

Motif(s):

Type	Positions	Sequence	Comment
	8 -> 139	VVSWQNGQALVSCDVKASCSSCASRAGCGSRVLNKLGPQTTHTIVVPCDEPLVPGQKVELGIAEGSLLSSALLVYMSPLVGLFLIASLFQLLFASDVAALCGAILGGIGGFLIARGYSRKFAARAEWQPIIL
	73 -> 95	SLLSSALLVYMSPLVGLFLIASL	UniProt: Helical.
	99 -> 121	LFASDVAALCGAILGGIGGFLIA	UniProt: Helical.

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.1 - sigma factors, anti-sigmafactors
		5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
		5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
		6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0016021 - integral component of membrane
	biological_process	GO:0006979 - response to oxidative stress

Note(s):

Note(s): ...[more].

Evidence:

[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Koo MS., et al., 2003

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

rseD-rpoE-rseABC

Operon arrangement:

Transcription unit	Promoter
rseABC	rseAp3
rpoE-rseABC	rpoEp
rpoE-rseABC	rpoEp2a
rpoE-rseABC	rpoEp5
rpoE-rseABC	rpoEp1a
rpoE-rseABC	rpoEp4
rpoE-rseABC	rpoEp2b
rpoE-rseABC	rseDp
rpoE-rseABC	rpoEp1b

Transcriptional Regulation
	Display Regulation
Activated by:	CRP, NtrC, GlrR, RcsB
Repressed by:	CpxR, IHF

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	lepBp1	2705464	reverse	nd	[COMP-AINF]	[2]
promoter	TSS_2866	2706051	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_2867	2707204	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_2868 (cluster)	2707211	reverse	nd	[RS-EPT-CBR]	[3]
promoter	TSS_2869	2709043	reverse	nd	[RS-EPT-CBR]	[3]

Evidence
[COMP-AINF] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Koo MS., Lee JH., Rah SY., Yeo WS., Lee JW., Lee KL., Koh YS., Kang SO., Roe JH., 2003, A reducing system of the superoxide sensor SoxR in Escherichia coli., EMBO J 22(11):2614-22
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.