RegulonDB

RegulonDB RegulonDB 11.1: Gene Form

truD gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	truD
Synonym(s):	ECK2740, G7422, b2745, ygbO
Genome position(nucleotides):	2870255 <-- 2871304
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.19
External database links:

ASAP:	ABE-0009011
ECHOBASE:	EB2912
ECOLIHUB:	truD
OU-MICROARRAY:	b2745
STRING:	511145.b2745
COLOMBOS:	truD

Product

Name:

tRNA pseudouridine¹³ synthase

Synonym(s):

TruD, YgbO

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

39.091

Isoelectric point:

6.532

Motif(s):

Type	Positions	Sequence	Comment
	8 -> 167	TYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGI
	31 -> 31	E	UniProt: Loss of activity..
	79 -> 79	K	UniProt: 10-fold decrease in activity..
	80 -> 80	D	UniProt: Loss of activity..
	87 -> 87	Q	UniProt: 3-fold decrease in activity..

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		2 - information transfer --> 2.2 - RNA related --> 2.2.3 - RNA modification
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0106029 - tRNA pseudouridine synthase activity GO:0016853 - isomerase activity GO:0003723 - RNA binding GO:0009982 - pseudouridine synthase activity
	biological_process	GO:0009451 - RNA modification GO:0001522 - pseudouridine synthesis GO:0031119 - tRNA pseudouridine synthesis GO:0008033 - tRNA processing

Note(s):

Note(s): ...[more].

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PDB:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

truD

Operon arrangement:

Transcription unit	Promoter
truD

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	ispFp2	2871911		reverse	nd	[COMP-AINF]	[1]
	promoter	ispFp3	2871984		reverse	nd	[COMP-AINF]	[1]

Evidence
[COMP-AINF] Inferred computationally without human oversight

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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