Gene
Name:	yqhD
Synonym(s):	ECK3003, G7564, b3011
Genome position(nucleotides):	3155355 --> 3156518 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	54.64
External database links:

ASAP:	ABE-0009888
ECHOBASE:	EB2834
ECOLIHUB:	yqhD
OU-MICROARRAY:	b3011
STRING:	511145.b3011
COLOMBOS:	yqhD

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_3318	3155303	forward	nd	[RS-EPT-CBR]	[12]
promoter	yqhCp1	3155384	reverse	nd	[ICWHO]	[13]
promoter	TSS_3319	3156572	forward	nd	[RS-EPT-CBR]	[12]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Geddes RD., Wang X., Yomano LP., Miller EN., Zheng H., Shanmugam KT., Ingram LO., 2014, Polyamine transporters and polyamines increase furfural tolerance during xylose fermentation with ethanologenic Escherichia coli strain LY180., Appl Environ Microbiol 80(19):5955-64
[2] Lee C., Kwon M., Lee K., Min H., Kim SH., Lee N., Kim J., Kim D., Ko C., Park C., 2016, Screening for Escherichia coli K-12 genes conferring glyoxal resistance or sensitivity by transposon insertions., FEMS Microbiol Lett 363(18)
[3] Lee C., Park C., 2012, Development of a suicidal vector-cloning system based on butanal susceptibility due to an expression of YqhD aldehyde reductase., J Microbiol 50(2):249-55
[4] Lee SS., Choi JI., Woo HM., 2019, Bioconversion of Xylose to Ethylene Glycol and Glycolate in Engineered Corynebacterium glutamicum., ACS Omega 4(25):21279-21287
[5] Lu X., Yao Y., Yang Y., Zhang Z., Gu J., Mojovic L., Knezevic-Jugovic Z., Baganz F., Lye G., Shi J., Hao J., 2020, Ethylene glycol and glycolic acid production by wild-type Escherichia coli., Biotechnol Appl Biochem
[6] McCloskey D., Xu S., Sandberg TE., Brunk E., Hefner Y., Szubin R., Feist AM., Palsson BO., 2018, Adaptation to the coupling of glycolysis to toxic methylglyoxal production in tpiA deletion strains of Escherichia coli requires synchronized and counterintuitive genetic changes., Metab Eng 48:82-93
[7] Seo HM., Jeon JM., Lee JH., Song HS., Joo HB., Park SH., Choi KY., Kim YH., Park K., Ahn J., Lee H., Yang YH., 2016, Combinatorial application of two aldehyde oxidoreductases on isobutanol production in the presence of furfural., J Ind Microbiol Biotechnol 43(1):37-44
[8] Song X., Yu H., Zhu K., 2016, Improving alkane synthesis in Escherichia coli via metabolic engineering., Appl Microbiol Biotechnol 100(2):757-67
[9] Tokuyama K., Ohno S., Yoshikawa K., Hirasawa T., Tanaka S., Furusawa C., Shimizu H., 2014, Increased 3-hydroxypropionic acid production from glycerol, by modification of central metabolism in Escherichia coli., Microb Cell Fact 13:64
[10] Tsuruno K., Honjo H., Hanai T., 2015, Enhancement of 3-hydroxypropionic acid production from glycerol by using a metabolic toggle switch., Microb Cell Fact 14:155
[11] Zhan Y., Zhou M., Wang H., Chen L., Li Z., Cai D., Wen Z., Ma X., Chen S., 2020, Efficient synthesis of 2-phenylethanol from L-phenylalanine by engineered Bacillus licheniformis using molasses as carbon source., Appl Microbiol Biotechnol 104(17):7507-7520
[12] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[13] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Transcriptional Regulation
	Display Regulation
Activated by:	YqhC