RegulonDB RegulonDB 11.1: Gene Form
   

mzrA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yqjA mzrA yqjC TSS_3404 TSS_3404 TSS_3403 (cluster) TSS_3403 (cluster) TSS_3402 (cluster) TSS_3402 (cluster) TSS_3401 TSS_3401 TSS_3400 (cluster) TSS_3400 (cluster) TSS_3399 (cluster) TSS_3399 (cluster) TSS_3398 TSS_3398 TSS_3397 TSS_3397 TSS_3396 TSS_3396 TSS_3395 TSS_3395 TSS_3394 TSS_3394 TSS_3393 TSS_3393

Gene      
Name: mzrA    Texpresso search in the literature
Synonym(s): ECK3087, G7610, b3096, ecfM, yqjB
Genome position(nucleotides): 3248439 --> 3248822
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.91
External database links:  
ASAP:
 ABE-0010183
ECHOBASE:
 EB2597
ECOLIHUB:
 mzrA
OU-MICROARRAY:
 b3096
STRING:
 511145.b3096
COLOMBOS: mzrA


Product      
Name: modulator protein MzrA
Synonym(s): EcfM, MzrA, YqjB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 14.172
Isoelectric point: 10.101
Motif(s):
 
Type Positions Sequence Comment
11 -> 31 LAWSGAVLLLVGTLLLAWSAV UniProt: Helical.
17 -> 104 VLLLVGTLLLAWSAVRQQESTLAIRAVHQGTTMPDGFSIWHHLDAHGIPFKSITPKNDTLLITFDSSDQSAAAKAVLDRTLPHGYIIA
51 -> 51 D UniProt: Loss of activity. Decreases interaction with EnvZ..
67 -> 67 K UniProt: No change in activity..
74 -> 74 D UniProt: No change in activity..

 
Classification:
Multifun Terms (GenProtEC)  
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0019901 - protein kinase binding
biological_process GO:0045859 - regulation of protein kinase activity
Note(s): Note(s): ...[more].
Evidence: [EXP-IEP] Inferred from expression pattern
Reference(s): [1] Gerken H., et al., 2009
External database links:  
ALPHAFOLD:
 P42615
ECOCYC:
 G7610-MONOMER
ECOLIWIKI:
 b3096
INTERPRO:
 IPR026574
INTERPRO:
 IPR027398
PFAM:
 PF13721
PRIDE:
 P42615
REFSEQ:
 NP_417567
SMR:
 P42615
UNIPROT:
 P42615


Operon      
Name: yqjA-mzrA         
Operon arrangement:
Transcription unit        Promoter
yqjA-mzrA
yqjA-mzrA


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3393 3247928 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3394 3248132 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3395 3248267 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3396 3248277 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3397 3248288 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3398 3248312 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3399 (cluster) 3248314 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3400 (cluster) 3248319 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3401 3248969 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3402 (cluster) 3249228 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3403 (cluster) 3249266 forward nd [RS-EPT-CBR] [2]
  promoter TSS_3404 3249284 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Gerken H., Charlson ES., Cicirelli EM., Kenney LJ., Misra R., 2009, MzrA: a novel modulator of the EnvZ/OmpR two-component regulon., Mol Microbiol 72(6):1408-22

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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