RegulonDB

Gene
Name:	mzrA
Synonym(s):	ECK3087, G7610, b3096, ecfM, yqjB
Genome position(nucleotides):	3248439 --> 3248822 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.91
External database links:

ASAP:	ABE-0010183
ECHOBASE:	EB2597
ECOLIHUB:	mzrA
OU-MICROARRAY:	b3096
STRING:	511145.b3096
COLOMBOS:	mzrA

Product

Name:

modulator protein MzrA

Synonym(s):

EcfM, MzrA, YqjB

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

14.172

Isoelectric point:

10.101

Motif(s):

Type	Positions	Sequence
	51 -> 51	D
	67 -> 67	K
	78 -> 78	I
	11 -> 31	LAWSGAVLLLVGTLLLAWSAV
	17 -> 104	VLLLVGTLLLAWSAVRQQESTLAIRAVHQGTTMPDGFSIWHHLDAHGIPFKSITPKNDTLLITFDSSDQSAAAKAVLDRTLPHGYIIA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0005515 - protein binding GO:0019901 - protein kinase binding
	biological_process	GO:0045859 - regulation of protein kinase activity

Note(s):

Note(s): ...[more].

Evidence:

[IEP] Inferred from expression pattern

Reference(s):

[1] Gerken H., et al., 2009

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

yqjA-mzrA

Operon arrangement:

Transcription unit	Promoter
yqjA-mzrA	yqjAp1
yqjA-mzrA	yqjAp2

Transcriptional Regulation
	Display Regulation
Activated by:	CpxR

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_3393	3247928	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3394	3248132	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3395	3248267	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3396	3248277	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3397	3248288	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3398	3248312	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3399 (cluster)	3248314	forward	For this promoter, there is a cluster of 4 transcription start sites,in the interval 3248314 to 3248317, where the highest frequency is at position 3246338. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	TSS_3400 (cluster)	3248319	forward	For this promoter, there is a cluster of 5 transcription start sites,in the interval 3248319 to 3248323, where the highest frequency is at position 3246342. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	TSS_3401	3248969	forward	nd	[RS-EPT-CBR]	[2]
promoter	TSS_3402 (cluster)	3249228	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 3249228 to 3249229, where the highest frequency is at position 3247251. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	TSS_3403 (cluster)	3249266	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 3249266 to 3249267, where the highest frequency is at position 3247289. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	TSS_3404	3249284	forward	nd	[RS-EPT-CBR]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Gerken H., Charlson ES., Cicirelli EM., Kenney LJ., Misra R., 2009, MzrA: a novel modulator of the EnvZ/OmpR two-component regulon., Mol Microbiol 72(6):1408-22
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Gerken H., Charlson ES., Cicirelli EM., Kenney LJ., Misra R., 2009, MzrA: a novel modulator of the EnvZ/OmpR two-component regulon., Mol Microbiol 72(6):1408-22

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.