RegulonDB RegulonDB 11.1: Gene Form
   

dgoR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dgoK dgoR yidX dgoA dgoD CRP DgoR DgoR TSS_4257 TSS_4257 dgoRp dgoRp

Gene      
Name: dgoR    Texpresso search in the literature
Synonym(s): ECK3687, G7789, b3694, b3695, b4479, yidW
Genome position(nucleotides): 3874471 <-- 3875160
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.36
External database links:  
ASAP:
 ABE-0174108
ECHOBASE:
 EB1669
ECOLIHUB:
 dgoR
OU-MICROARRAY:
 b3694
STRING:
 511145.b4479
COLOMBOS: dgoR


Product      
Name: DNA-binding transcriptional regulator DgoR
Synonym(s): DgoR, YidW
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 26.08
Isoelectric point: 5.397
Motif(s):
 
Type Positions Sequence Comment
1 -> 71 MTLNKTDRIVITLGKQIVHGKYVPGSPLPAEAELCEEFATSRNIIREVFRSLMAKRLIEMKRYRGAFVAPR UniProt: HTH gntR-type.
7 -> 68 DRIVITLGKQIVHGKYVPGSPLPAEAELCEEFATSRNIIREVFRSLMAKRLIEMKRYRGAFV
31 -> 50 EAELCEEFATSRNIIREVFR UniProt: H-T-H motif.
99 -> 218 SEVRNLVEPAIARWAAERATSSDLAQIESALNEMIANNQDREAFNEADIRYHEAVLQSVHNPVLQQLSIAISSLQRAVFERTWMGDEANMPQTLQEHKALFDAIRHQDGDAAEQAALTMI
111 -> 112 RW UniProt: In Ref. 1; AAA62046..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
  3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0098531 - ligand-activated transcription factor activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0042802 - identical protein binding
GO:0000976 - transcription cis-regulatory region binding
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001217 - DNA-binding transcription repressor activity
biological_process GO:0006355 - regulation of transcription, DNA-templated
GO:2000143 - negative regulation of DNA-templated transcription, initiation
GO:0010677 - negative regulation of cellular carbohydrate metabolic process
External database links:  
ALPHAFOLD:
 P31460
DIP:
 DIP-9435N
ECOCYC:
 G7790-MONOMER
ECOLIWIKI:
 b4479
INTERPRO:
 IPR036390
INTERPRO:
 IPR036388
INTERPRO:
 IPR011711
INTERPRO:
 IPR000524
INTERPRO:
 IPR008920
MODBASE:
 P31460
PFAM:
 PF07729
PFAM:
 PF00392
PRIDE:
 P31460
PRINTS:
 PR00035
PROSITE:
 PS50949
REFSEQ:
 YP_026239
SMART:
 SM00895
SMART:
 SM00345
SMR:
 P31460
UNIPROT:
 P31460


Operon      
Name: dgoRKADT         
Operon arrangement:
Transcription unit        Promoter
dgoRKADT


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: DgoR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4257 3875186 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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