RegulonDB

RegulonDB RegulonDB 11.1: Gene Form

iadA gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	iadA
Synonym(s):	ECK4319, G7925, b4328, yjiF
Genome position(nucleotides):	4558354 <-- 4559526
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	56.61
External database links:

ASAP:	ABE-0014195
ECHOBASE:	EB2455
ECOLIHUB:	iadA
OU-MICROARRAY:	b4328
STRING:	511145.b4328
COLOMBOS:	iadA

Product

Name:

isoaspartyl dipeptidase

Synonym(s):

IadA, YjiF

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

41.084

Isoelectric point:

4.902

Motif(s):

Type	Positions	Sequence	Comment
	75 -> 77	GGE	UniProt: Substrate binding; Sequence Annotation Type: region of interest.
	77 -> 77	E	UniProt: Reduces activity 100000-fold..
	137 -> 137	Y	UniProt: Reduces activity 1000-fold..
	169 -> 169	R	UniProt: Loss of activity..
	233 -> 233	R	UniProt: Loss of activity..

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
		2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0008233 - peptidase activity GO:0016787 - hydrolase activity GO:0046872 - metal ion binding GO:0016810 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0008270 - zinc ion binding GO:0008237 - metallopeptidase activity GO:0042802 - identical protein binding GO:0008798 - beta-aspartyl-peptidase activity
	biological_process	GO:0006508 - proteolysis

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

yjiHG-iadA

Operon arrangement:

Transcription unit	Promoter
yjiHG-iadA

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	hypTp4	4558317		reverse	nd	[COMP-AINF]	[1]
	promoter	iadAp3	4559537		reverse	nd	[COMP-AINF]	[1]

Evidence
[COMP-AINF] Inferred computationally without human oversight

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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