RegulonDB RegulonDB 11.1: Gene Form
   

mhpB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mhpA mhpB mhpC anti-anti-terminator anti-terminator

Gene      
Name: mhpB    Texpresso search in the literature
Synonym(s): ECK0345, M011, b0348
Genome position(nucleotides): 370277 --> 371221
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 57.78
External database links:  
ASAP:
 ABE-0001198
ECHOBASE:
 EB4167
ECOLIHUB:
 mhpB
OU-MICROARRAY:
 b0348
STRING:
 511145.b0348
COLOMBOS: mhpB


Product      
Name: 3-carboxyethylcatechol 2,3-dioxygenase
Synonym(s): 2,3-dihydroxyphenylpropionate/2,3-dihydroxycinnamate 1,2-dioxygenase, MhpB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 34.196
Isoelectric point: 5.347
Motif(s):
 
Type Positions Sequence Comment
4 -> 306 YLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFG
114 -> 114 D UniProt: Low level of catalytic activity, 600-fold lower than the wild-type enzyme. More than 8000-fold decrease in affinity..
115 -> 115 H UniProt: Complete loss of activity..
138 -> 140 ING UniProt: In Ref. 1; BAA13053..
152 -> 152 R UniProt: In Ref. 1; BAA13053..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.2 - fatty acids
Gene Ontology Terms (GO)  
cellular_component GO:0005886 - plasma membrane
molecular_function GO:0016491 - oxidoreductase activity
GO:0005506 - iron ion binding
GO:0008198 - ferrous iron binding
GO:0047070 - 3-carboxyethylcatechol 2,3-dioxygenase activity
GO:0051213 - dioxygenase activity
biological_process GO:0006725 - cellular aromatic compound metabolic process
GO:0019439 - aromatic compound catabolic process
GO:0019380 - 3-phenylpropionate catabolic process
GO:0019622 - 3-(3-hydroxy)phenylpropionate catabolic process
GO:0046271 - phenylpropanoid catabolic process
External database links:  
ALPHAFOLD:
 P0ABR9
DIP:
 DIP-10206N
ECOCYC:
 DHPDIOXYGEN-MONOMER
ECOLIWIKI:
 b0348
INTERPRO:
 IPR004183
INTERPRO:
 IPR023789
MODBASE:
 P0ABR9
PFAM:
 PF02900
PRIDE:
 P0ABR9
PRODB:
 PRO_000023229
REFSEQ:
 NP_414882
UNIPROT:
 P0ABR9


Operon      
Name: mhpABCDFE         
Operon arrangement:
Transcription unit        Promoter
mhpABCDFE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, MhpR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB