RegulonDB RegulonDB 10.10: Gene Form
   

istR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

istR tisA ivbL tisB istR-1 LexA CRP  IstR-2  IstR-1  IstR-2  IstR-1 ppGpp anti-anti-terminator anti-terminator terminator anti-anti-terminator anti-terminator TSS_4252 TSS_4252 tisBp tisBp istR-2p istR-2p istR-1p istR-1p ivbLp ivbLp TSS_4251 TSS_4251

Gene      
Name: istR    Texpresso search in the literature
Synonym(s): ECK4425, G0-10201, b4616, istR-1, istR-2, psrA19
Genome position(nucleotides): 3853118 <-- 3853257 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.71
External database links:  
ECOLIHUB:
istR-2
COLOMBOS: istR


Product      
Name: small regulatory RNA IstR-1
Synonym(s): IstR-1
Type: small RNA
Classification:
Multifun Terms (GenProtEC)  
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional
Gene Ontology Terms (GO)  
molecular_function GO:0003729 - mRNA binding
GO:0048027 - mRNA 5'-UTR binding
biological_process GO:0040033 - negative regulation of translation, ncRNA-mediated
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
[IMP] Inferred from mutant phenotype
Reference(s): [1] Darfeuille F., et al., 2007
[2] Vogel J., et al., 2004
External database links:  
ECOCYC:
RNA0-282


Operon      
Name: istR         
Operon arrangement:
Transcription unit        Promoter
istR-1
istR-2


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4251 3853016 reverse nd [RS-EPT-CBR] [3]
  promoter TSS_4252 3853442 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Darfeuille F., Unoson C., Vogel J., Wagner EG., 2007, An antisense RNA inhibits translation by competing with standby ribosomes., Mol Cell 26(3):381-92

 [2] Vogel J., Argaman L., Wagner EG., Altuvia S., 2004, The small RNA IstR inhibits synthesis of an SOS-induced toxic peptide., Curr Biol 14(24):2271-6

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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