RegulonDB RegulonDB 11.1: Gene Form
   

mntS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mntR rybA yliL mntS ybiR MntR MntR TSS_979 TSS_979 mntRp4 mntRp4 mntRp mntRp mntRp5 mntRp5 mntRp6 mntRp6 rybAp rybAp TSS_978 TSS_978

Gene      
Name: mntS    Texpresso search in the literature
Synonym(s): ECK4517, G0-10715, G0-8881, b4705
Genome position(nucleotides): 852869 <-- 852997
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 41.09


Product      
Name: small protein MntS
Synonym(s): MntS
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 5.031
Isoelectric point: 10.218
Classification:
Multifun Terms (GenProtEC)  
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
biological_process GO:0030026 - cellular manganese ion homeostasis
GO:0071287 - cellular response to manganese ion
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Duval M., et al., 2017
[2] Martin JE., et al., 2015
[3] PLOS Genetics Staff. 2015
External database links:  
ALPHAFOLD:
 P0DKB3
ECOCYC:
 MONOMER0-4216
PRIDE:
 P0DKB3
REFSEQ:
 YP_009029995
SMR:
 P0DKB3
UNIPROT:
 P0DKB3


Operon      
Name: rybA-mntS         
Operon arrangement:
Transcription unit        Promoter
rybA-mntS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ybiPp5 852626 reverse nd [COMP-AINF] [4]
  promoter TSS_978 853047 reverse nd [RS-EPT-CBR] [5]
  promoter mntRp6 853080 forward nd [COMP-AINF] [4]
  promoter mntRp5 853083 forward nd [COMP-AINF] [4]
  promoter mntRp4 853135 forward nd [COMP-AINF] [4]
  promoter TSS_979 853137 forward nd [RS-EPT-CBR] [5]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Duval M., Cossart P., 2017, Small bacterial and phagic proteins: an updated view on a rapidly moving field., Curr Opin Microbiol 39:81-88

 [2] Martin JE., Waters LS., Storz G., Imlay JA., 2015, The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese., PLoS Genet 11(3):e1004977

 [3] PLOS Genetics Staff., 2015, Correction: The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese., PLoS Genet 11(6):e1005322

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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