RegulonDB RegulonDB 10.9: Gene Form
   

argD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yhfK argD pabA ArgR ArgR PhoP argDp argDp TSS_3962 TSS_3962

Gene      
Name: argD    Texpresso search in the literature
Synonym(s): Arg1, ECK3347, EG10066, b3359, dapC, dtu
Genome position(nucleotides): 3488960 <-- 3490180 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
54.55
Reference(s): [1] Heimberg H., et al., 1990
[2] Ledwidge R., et al., 1999
External database links:  
ASAP:
ABE-0010976
CGSC:
1018
ECHOBASE:
EB0064
ECOLIHUB:
argD
ENTREZ:
M32796
MIM:
258870
NCBI-GENE:
947864
OU-MICROARRAY:
b3359
STRING:
511145.b3359
COLOMBOS: argD


Product      
Name: N-acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase
Synonym(s): ArgD, DapC, Dtu
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 43.767
Isoelectric point: 6.186
Motif(s):
 
Type Positions Sequence
26 -> 400 FIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAV
226 -> 229 DEVQ
245 -> 247 GVT
2 -> 406 AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPISAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEAGVMVLNAGPDVMRFAPSLVVEDADIDEGMQRFAHAVAKVVGA
108 -> 109 GT

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.3 - arginine
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.7 - lysine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016740 - transferase activity
GO:0008483 - transaminase activity
GO:0030170 - pyridoxal phosphate binding
GO:0003992 - N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO:0009016 - succinyldiaminopimelate transaminase activity
GO:0042802 - identical protein binding
biological_process GO:0006520 - cellular amino acid metabolic process
GO:0006525 - arginine metabolic process
GO:0006526 - arginine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0009085 - lysine biosynthetic process
GO:0009089 - lysine biosynthetic process via diaminopimelate
GO:0042450 - arginine biosynthetic process via ornithine
GO:0033359 - lysine biosynthetic process via diaminopimelate and N-succinyl-2-amino-6-ketopimelate
External database links:  
DIP:
DIP-9138N
ECOCYC:
ACETYLORNTRANSAM-MONOMER
ECOLIWIKI:
b3359
INTERPRO:
IPR005814
INTERPRO:
IPR017652
INTERPRO:
IPR015424
INTERPRO:
IPR015422
INTERPRO:
IPR015421
INTERPRO:
IPR004636
MODBASE:
P18335
PFAM:
PF00202
PRIDE:
P18335
PRODB:
PRO_000022128
PROSITE:
PS00600
REFSEQ:
NP_417818
SMR:
P18335
SWISSMODEL:
P18335
UNIPROT:
P18335


Operon      
Name: argD         
Operon arrangement:
Transcription unit        Promoter
argD


Transcriptional Regulation      
Display Regulation             
Repressed by: PhoP, ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3962 3490187 reverse nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Heimberg H., Boyen A., Crabeel M., Glansdorff N., 1990, Escherichia coli and Saccharomyces cerevisiae acetylornithine aminotransferase: evolutionary relationship with ornithine aminotransferase., Gene 90(1):69-78

 [2] Ledwidge R., Blanchard JS., 1999, The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis., Biochemistry 38(10):3019-24

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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