RegulonDB RegulonDB 11.1: Gene Form
   

pepT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pepT potA roxA terminator pepTp pepTp TSS_1464 TSS_1464 TSS_1463 TSS_1463

Gene      
Name: pepT    Texpresso search in the literature
Synonym(s): ECK1113, EG11549, b1127
Genome position(nucleotides): 1185844 --> 1187070
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 49.88
External database links:  
ASAP:
 ABE-0003800
CGSC:
 31914
ECHOBASE:
 EB1511
ECOLIHUB:
 pepT
OU-MICROARRAY:
 b1127
STRING:
 511145.b1127
COLOMBOS: pepT


Product      
Name: peptidase T
Synonym(s): PepT
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 44.923
Isoelectric point: 5.308
Motif(s):
 
Type Positions Sequence Comment
139 -> 402 ADDKAGIAEIMTALAVLQQKKIPHGDIRVAFTPDEEVGKGAKHFDVDAFDARWAYTVDGGGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADESPEMTEGYEGFYHLASMKGTVERADMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIEDSYYNMREKVVEHPHILDIAQQAMRDCDIEPELKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAE
206 -> 303 ENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADESPEMTEGYEGFYHLASMKGTVERADMHYIIRDFDRKQFEARKRKMMEIAKKVGK

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0008270 - zinc ion binding
GO:0004177 - aminopeptidase activity
GO:0008237 - metallopeptidase activity
GO:0045148 - tripeptide aminopeptidase activity
GO:0042803 - protein homodimerization activity
biological_process GO:0006508 - proteolysis
GO:0006518 - peptide metabolic process
GO:0043171 - peptide catabolic process
External database links:  
ALPHAFOLD:
 P29745
DIP:
 DIP-10461N
ECOCYC:
 EG11549-MONOMER
ECOLIWIKI:
 b1127
INTERPRO:
 IPR036264
INTERPRO:
 IPR002933
INTERPRO:
 IPR010161
INTERPRO:
 IPR011650
INTERPRO:
 IPR001261
MODBASE:
 P29745
PANTHER:
 PTHR42994:SF1
PDB:
 1VIX
PFAM:
 PF01546
PFAM:
 PF07687
PRIDE:
 P29745
PRODB:
 PRO_000023512
PROSITE:
 PS00759
PROSITE:
 PS00758
REFSEQ:
 NP_415645
SMR:
 P29745
SWISSMODEL:
 P29745
UNIPROT:
 P29745


Operon      
Name: pepT         
Operon arrangement:
Transcription unit        Promoter
pepT


Transcriptional Regulation      
Display Regulation             
Activated by: FNR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1463 1185738 forward nd [RS-EPT-CBR] [1]
  promoter TSS_1464 1185805 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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