Gene
Name:	hypF
Synonym(s):	ECK2707, EG11551, b2712, hydA
Genome position(nucleotides):	2835173 <-- 2837425
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	57.61
External database links:

ASAP:	ABE-0008915
CGSC:	18232
ECHOBASE:	EB1512
ECOLIHUB:	hypF
OU-MICROARRAY:	b2712
STRING:	511145.b2712
COLOMBOS:	hypF

Reference(s)
[1] Blbulyan S., Trchounian A., 2015, Impact of membrane-associated hydrogenases on the F₀F₁-ATPase in Escherichia coli during glycerol and mixed carbon fermentation: ATPase activity and its inhibition by N,N'-dicyclohexylcarbodiimide in the mutants lacking hydrogenases., Arch Biochem Biophys 579:67-72
[2] Gevorgyan H., Trchounian A., Trchounian K., 2018, Understanding the Role of Escherichia coli Hydrogenases and Formate Dehydrogenases in the F_O F₁ -ATPase Activity during the Mixed Acid Fermentation of Mixture of Carbon Sources., IUBMB Life 70(10):1040-1047
[3] Lee JH., Patel P., Sankar P., Shanmugam KT., 1985, Isolation and characterization of mutant strains of Escherichia coli altered in H2 metabolism., J Bacteriol 162(1):344-52
[4] Pascal MC., Casse F., Chippaux M., Lepelletier M., 1975, Genetic analysis of mutants of Escherichia coli K12 and Salmonella typhimurium LT2 deficient in hydrogenase activity., Mol Gen Genet 141(2):173-9
[5] Petkun S., Shi R., Li Y., Asinas A., Munger C., Zhang L., Waclawek M., Soboh B., Sawers RG., Cygler M., 2011, Structure of hydrogenase maturation protein HypF with reaction intermediates shows two active sites., Structure 19(12):1773-83
[6] Sankar P., Lee JH., Shanmugam KT., 1985, Cloning of hydrogenase genes and fine structure analysis of an operon essential for H2 metabolism in Escherichia coli., J Bacteriol 162(1):353-60
[7] Soboh B., Lindenstrauss U., Granich C., Javed M., Herzberg M., Thomas C., Stripp ST., 2014, [NiFe]-hydrogenase maturation in vitro: analysis of the roles of the HybG and HypD accessory proteins1., Biochem J 464(2):169-77
[8] Stripp ST., Lindenstrauss U., Sawers RG., Soboh B., 2015, Identification of an Isothiocyanate on the HypEF Complex Suggests a Route for Efficient Cyanyl-Group Channeling during [NiFe]-Hydrogenase Cofactor Generation., PLoS One 10(7):e0133118
[9] Trchounian K., Blbulyan S., Trchounian A., 2013, Hydrogenase activity and proton-motive force generation by Escherichia coli during glycerol fermentation., J Bioenerg Biomembr 45(3):253-60

Transcriptional Regulation
	Display Regulation
Activated by:	FhlA, FlhDC
Repressed by:	Cra