RegulonDB RegulonDB 11.1: Gene Form
   

mdtD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mdtC mdtD baeS baeR TSS_2404 TSS_2404

Gene      
Name: mdtD    Texpresso search in the literature
Synonym(s): ECK2073, EG12136, b2077, iceT, yegB
Genome position(nucleotides): 2161464 --> 2162879
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.51
External database links:  
ASAP:
 ABE-0006879
ECHOBASE:
 EB2057
ECOLIHUB:
 mdtD
OU-MICROARRAY:
 b2077
STRING:
 511145.b2077
COLOMBOS: mdtD


Product      
Name: putative multidrug efflux pump MdtD
Synonym(s): IceT, MdtD, YegB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 50.901
Isoelectric point: 10.877
Motif(s):
 
Type Positions Sequence Comment
12 -> 32 LWIVAFGFFMQSLDTTIVNTA UniProt: Helical.
15 -> 405 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADKVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARALQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLLLMPNYTMQTRRFDLSGFLLLAVGMAVLTLALDGSKGTGLSPLTIAGLVAVGVVALVLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTLGLSLVTLLFMTTALLGWYYVLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIG
49 -> 69 MVIVSYVLTVAVMLPASGWLA UniProt: Helical.
77 -> 97 IFFTAIVLFTLGSLFCALSGT UniProt: Helical.
102 -> 124 LLARALQGVGGAMMVPVGRLTVM UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
biological_process GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P36554
DIP:
 DIP-11876N
ECOCYC:
 B2077-MONOMER
ECOLIWIKI:
 b2077
INTERPRO:
 IPR023721
INTERPRO:
 IPR036259
INTERPRO:
 IPR020846
INTERPRO:
 IPR011701
INTERPRO:
 IPR004638
MODBASE:
 P36554
PANTHER:
 PTHR23501
PFAM:
 PF07690
PRIDE:
 P36554
PROSITE:
 PS50850
REFSEQ:
 NP_416581
UNIPROT:
 P36554


Operon      
Name: mdtABCD-baeSR         
Operon arrangement:
Transcription unit        Promoter
mdtABCD-baeSR
baeSR


Transcriptional Regulation      
Display Regulation             
Activated by: BaeR, CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2404 2164246 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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