RegulonDB RegulonDB 11.1: Gene Form
   

citT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

citT citG rna citX anti-terminator terminator citTp4 citTp4 citTp6 citTp6 rnap rnap

Gene      
Name: citT    Texpresso search in the literature
Synonym(s): ECK0605, G6338, b0612, ybdS
Genome position(nucleotides): 645117 <-- 646580
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.61
External database links:  
ASAP:
 ABE-0002110
ECHOBASE:
 EB3308
ECOLIHUB:
 citT
OU-MICROARRAY:
 b0612
STRING:
 511145.b0612
COLOMBOS: citT


Product      
Name: citrate:succinate antiporter
Synonym(s): CitT, CitT citrate DASS Transporter, YbdS
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 53.093
Isoelectric point: 8.843
Motif(s):
 
Type Positions Sequence Comment
6 -> 486 DNIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDAKELADPAFNAQKQALKWGLAGFSSTTVWLVFGAFIFALGYEVSGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVSKIAGIQISWLQWFLCFLPVGVILLIIAPWLSYVLYKPEITHSEEVATWAGDELKTMGALTRREWTLIGLVLLSLGLWVFGSEVINATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFAGTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKGIPGVPMEQLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYISMLLLVGWPILAMW
11 -> 31 LLAPLVVMGVMFLIPVPDGMP UniProt: Helical.
60 -> 80 FIAVTICVIGSNYLLFDAKEL UniProt: Helical.
95 -> 115 GLAGFSSTTVWLVFGAFIFAL UniProt: Helical.
138 -> 158 TLTLGYAIVIIDILLAPFTPS UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015297 - antiporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Sasatsu M., et al., 1985
External database links:  
ALPHAFOLD:
 P0AE74
ECOCYC:
 B0612-MONOMER
ECOLIWIKI:
 b0612
INTERPRO:
 IPR001898
INTERPRO:
 IPR030676
PANTHER:
 PTHR42826
PFAM:
 PF00939
PRIDE:
 P0AE74
PRODB:
 PRO_000022292
REFSEQ:
 NP_415145
UNIPROT:
 P0AE74


Operon      
Name: citT         
Operon arrangement:
Transcription unit        Promoter
citT


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter citTp6 646603 reverse nd [COMP-AINF] [2]
  promoter citTp4 646632 reverse nd [COMP-AINF] [2]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Sasatsu M., Misra TK., Chu L., Laddaga R., Silver S., 1985, Cloning and DNA sequence of a plasmid-determined citrate utilization system in Escherichia coli., J Bacteriol 164(3):983-93

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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