RegulonDB RegulonDB 10.10: Gene Form
   

digH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gadC yddW yddY terminator yddWp6 yddWp6

Gene      
Name: digH    Texpresso search in the literature
Synonym(s): ECK1485, G6785, b1491, yddW
Genome position(nucleotides): 1567504 <-- 1568823 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.35
External database links:  
ASAP:
 ABE-0004970
ECHOBASE:
 EB3555
ECOLIHUB:
 yddW
OU-MICROARRAY:
 b1491
STRING:
 511145.b1491
COLOMBOS: digH


Product      
Name: divisome localized glycosyl hydrolase
Synonym(s): DigH, YddW
Sequence: Get amino acid sequence Fasta Format
Cellular location: outer membrane,periplasmic space
Molecular weight: 49.574
Isoelectric point: 9.589
Motif(s):
 
Type Positions Sequence
236 -> 236 D
55 -> 390 PMRGIWLATVSRLDWPPVSSVNISNPTSRARVQQQAMIDKLDHLQRLGINTVFFQVKPDGTALWPSKILPWSDLMTGKIGENPGYDPLQFMLDEAHKRGMKVHAWFNPYRVSVNTKPGTIRELNSTLSQQPASVYVQHRDWIRTSGDRFVLDPGIPEVQDWITSIVAEVVSRYPVDGVQFDDYFYTESPGSRLNDNETYRKYGGAFASKADWRRNNTQQLIAKVSHTIKSIKPGVEFGVSPAGVWRNRSHDPLGSDTRGAAAYDESYADTRRWVEQGLLDYIAPQIYWPFSRSAARYDVLAKWWADVVKPTRTRLYIGIAFYKVGEPSKIEPDWMI
1 -> 27 MDICSRNKKLTIRRPAILVALALLLCS
28 -> 439 CKSTPPESMVTPPAGSKPPATTQQSSQPMRGIWLATVSRLDWPPVSSVNISNPTSRARVQQQAMIDKLDHLQRLGINTVFFQVKPDGTALWPSKILPWSDLMTGKIGENPGYDPLQFMLDEAHKRGMKVHAWFNPYRVSVNTKPGTIRELNSTLSQQPASVYVQHRDWIRTSGDRFVLDPGIPEVQDWITSIVAEVVSRYPVDGVQFDDYFYTESPGSRLNDNETYRKYGGAFASKADWRRNNTQQLIAKVSHTIKSIKPGVEFGVSPAGVWRNRSHDPLGSDTRGAAAYDESYADTRRWVEQGLLDYIAPQIYWPFSRSAARYDVLAKWWADVVKPTRTRLYIGIAFYKVGEPSKIEPDWMINGGVPELKKQLDLNDAVPEISGTILFREDYLNKPQTQQAVSYLQSRWGS

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.1 - cell division
Gene Ontology Terms (GO)  
cellular_component GO:0009279 - cell outer membrane
GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0036405 - anchored component of cell outer membrane
molecular_function GO:0003824 - catalytic activity
GO:0016787 - hydrolase activity
GO:0016798 - hydrolase activity, acting on glycosyl bonds
biological_process GO:0008152 - metabolic process
GO:0071555 - cell wall organization
Note(s): Note(s): ...[more].
Reference(s): [1] Rao S., et al., 2020
External database links:  
DIP:
 DIP-48187N
ECOCYC:
 G6785-MONOMER
ECOLIWIKI:
 b1491
INTERPRO:
 IPR017853
INTERPRO:
 IPR013785
INTERPRO:
 IPR003790
MODBASE:
 P64426
PFAM:
 PF02638
PRIDE:
 P64426
PROSITE:
 PS51257
REFSEQ:
 NP_416008
SMR:
 P64426
UNIPROT:
 P64426


Operon      
Name: digH         
Operon arrangement:
Transcription unit        Promoter
digH


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yddWp6 1568852 reverse nd [ICWHO] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Rao S., Bates GT., Matthews CR., Newport TD., Vickery ON., Stansfeld PJ., 2020, Characterizing Membrane Association and Periplasmic Transfer of Bacterial Lipoproteins through Molecular Dynamics Simulations., Structure 28(4):475-487.e3

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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