RegulonDB

Gene
Name:	uidR
Synonym(s):	ECK1613, G6867, b1618, gusR
Genome position(nucleotides):	1696462 <-- 1697052
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.93
External database links:

ASAP:	ABE-0005415
ECHOBASE:	EB2533
ECOLIHUB:	uidR
OU-MICROARRAY:	b1618
STRING:	511145.b1618
COLOMBOS:	uidR

Product

Name:

DNA-binding transcriptional repressor UidR

Synonym(s):

GusR, UidR

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

TetR/AcrR

Cellular location:

cytosol

Molecular weight:

21.799

Isoelectric point:

5.944

Motif(s):

Type	Positions	Sequence	Comment
	10 -> 70	QPTRTRILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQAIILQDQERA	UniProt: HTH tetR-type.
	16 -> 62	ILNAAREIFSENGFHSASMKAICKSCAISPGTLYHHFISKEALIQAI
	33 -> 52	SMKAICKSCAISPGTLYHHF	UniProt: H-T-H motif.

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0000976 - transcription cis-regulatory region binding
	biological_process	GO:0006351 - transcription, DNA-templated GO:0006355 - regulation of transcription, DNA-templated GO:0045892 - negative regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[EXP-IEP] Inferred from expression pattern
[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis

Reference(s):

[1] Blanco C. 1987
[2] Blanco C., et al., 1985
[3] Blanco C., et al., 1986
[4] Blanco C., et al., 1982
[5] Novel M., et al., 1976
[6] Novel M., et al., 1976

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

uidR

Operon arrangement:

Transcription unit	Promoter
uidR	uidRp

Transcriptional Regulation
	Display Regulation
Repressed by:	UidR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_1898	1697074		reverse	nd	[RS-EPT-CBR]	[7]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Blanco C., 1987, Transcriptional and translational signals of the uidA gene in Escherichia coli K12., Mol Gen Genet 208(3):490-8
[2] Blanco C., Mata-Gilsinger M., Ritzenthaler P., 1985, The use of gene fusions to study the expression of uidR, a negative regulatory gene of Escherichia coli K-12., Gene 36(1-2):159-67
[3] Blanco C., Ritzenthaler P., Mata-Gilsinger M., 1986, Negative dominant mutations of the uidR gene in Escherichia coli: genetic proof for a cooperative regulation of uidA expression., Genetics 112(2):173-82
[4] Blanco C., Ritzenthaler P., Mata-Gilsinger M., 1982, Cloning and endonuclease restriction analysis of uidA and uidR genes in Escherichia coli K-12: determination of transcription direction for the uidA gene., J Bacteriol 149(2):587-94
[5] Novel M., Novel G., 1976, Regulation of beta-glucuronidase synthesis in Escherichia coli K-12: constitutive mutants specifically derepressed for uidA expression., J Bacteriol 127(1):406-17
[6] Novel M., Novel G., 1976, Regulation of beta-glucuronidase synthesis in Escherichia coli K-12: pleiotropic constitutive mutations affecting uxu and uidA expression., J Bacteriol 127(1):418-32
[7] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.