RegulonDB

Gene
Name:	exoX
Synonym(s):	ECK1845, G7016, b1844, yobC
Genome position(nucleotides):	1926120 --> 1926782
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.89
External database links:

ASAP:	ABE-0006131
ECHOBASE:	EB3785
ECOLIHUB:	exoX
OU-MICROARRAY:	b1844
STRING:	511145.b1844
COLOMBOS:	exoX

Product

Name:

exonuclease X

Synonym(s):

ExoX, YobC

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

25.133

Isoelectric point:

7.658

Motif(s):

Type	Positions	Sequence	Comment
	4 -> 147	IIDTETCGLQGGIVEIASVDVIDGKIVNPMSHLVRPDRPISPQAMAIHRITEAMVADKPWIEDVIPHYYGSEWYVAHNASFDRRVLPEMPGEWICTMKLARRLWPGIKYSNMALYKTRKLNVQTPPGLHHHRALYDCYITAALL
	174 -> 203	FTFGKYRGKAVSDVAERDPGYLRWLFNNLD

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.2 - DNA
		2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
		2 - information transfer --> 2.1 - DNA related --> 2.1.5 - DNA degradation
		5 - cell processes --> 5.6 - protection --> 5.6.1 - radiation
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003676 - nucleic acid binding GO:0004518 - nuclease activity GO:0004527 - exonuclease activity GO:0016787 - hydrolase activity GO:0008408 - 3'-5' exonuclease activity
	biological_process	GO:0006281 - DNA repair GO:0006974 - cellular response to DNA damage stimulus GO:0045004 - DNA replication proofreading GO:0006298 - mismatch repair GO:0090305 - nucleic acid phosphodiester bond hydrolysis

Note(s):

Note(s): ...[more].

Evidence:

[EXP-IDA-PURIFIED-PROTEIN] Assay of protein purified to homogeneity
[EXP-IGI] Inferred from genetic interaction

Reference(s):

[1] Burdett V., et al., 2001
[2] Feschenko VV., et al., 2003
[3] Viswanathan M., et al., 2001
[4] Viswanathan M., et al., 1999

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PDB:

PFAM:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

yobB-exoX

Operon arrangement:

Transcription unit	Promoter
yobB-exoX

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_2187 (cluster)	1926096		forward	nd	[RS-EPT-CBR]	[5]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Burdett V., Baitinger C., Viswanathan M., Lovett ST., Modrich P., 2001, In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair., Proc Natl Acad Sci U S A 98(12):6765-70
[2] Feschenko VV., Rajman LA., Lovett ST., 2003, Stabilization of perfect and imperfect tandem repeats by single-strand DNA exonucleases., Proc Natl Acad Sci U S A 100(3):1134-9
[3] Viswanathan M., Burdett V., Baitinger C., Modrich P., Lovett ST., 2001, Redundant exonuclease involvement in Escherichia coli methyl-directed mismatch repair., J Biol Chem 276(33):31053-8
[4] Viswanathan M., Lovett ST., 1999, Exonuclease X of Escherichia coli. A novel 3'-5' DNase and Dnaq superfamily member involved in DNA repair., J Biol Chem 274(42):30094-100
[5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.